ReviewJournal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures)2024
Feeding Intolerance in Critically Ill Patients with Enteral Nutrition: A Meta-Analysis and Systematic Review.
Review in Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevalence and risk factors for feeding intolerance in geriatric patients following nasogastric tube nutrition: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Diagnostic accuracy of gastrointestinal ultrasound in predicting enteral feeding intolerance: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Association between age and outcomes of evidence-based feeding protocol versus usual care in critically ill patients: secondary analysis of a multicenter cluster-randomised controlled trial.Journal of intensive care · 2026Article
- Prevalence, risk factors, and clinical consequence of enteral feeding intolerance in elderly patients with traumatic brain injury: a two-center study.European journal of clinical nutrition · 2026Article
- Machine Learning-Driven Prediction of Early Enteral Nutrition Intolerance in ICU Patients Using Intra-Abdominal Pressure and Selected Gut Microbial Taxa.Polish journal of microbiology · 2026Article
- Gut microecology in critical illness: mechanisms, biomarkers, and therapeutic strategies - a critical appraisal.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Review
- Early supplemental parenteral nutrition and risk of subsequent enteroatmospheric fistula in high-risk open abdomen patients with persistent enteral nutrition intolerance: a landmark propensity score-matched cohort study.Frontiers in medicine · 2026Article
- Development and evaluation of a machine learning-based risk prediction model for enteral feeding intolerance in sepsis patients.Frontiers in nutrition · 2026Article
- Precision nutrition in critical illness: a phase-specific framework from acute feeding to post-ICU recovery.Frontiers in nutrition · 2026Review
- Advancements in research on feeding intolerance to enteral nutrition in neurocritical patients undergoing sedation and analgesia.Frontiers in nutrition · 2026Review
- Interruption of enteral tube feeding during chest physiotherapy in critically ill adults: A scoping review.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2026Review
- Gastrointestinal complications in intensive care.Medical review (2021) · 2025Review
- Article
- The impact of enteral feeding intolerance on the prognosis of patients with septic shock in South Korea.Acute and critical care · 2025Article
- Impact of Protein and Nutritional Support on the Muscular Status of Critically Ill Patients: A Pilot, Perspective, and Exploratory Study.Nutrients · 2025Article
- Enteral nutritional support for an elderly critically ill patient with gastroesophageal reflux disease and situs inversus totalis: a case report.Frontiers in nutrition · 2025Article
- The implementation gap in critical care: From nutrition to ventilation.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2025Article
- Optimizing Nutrient Uptake in the Critically Ill: Insights into Malabsorption Management.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Feeding intolerance is a common yet serious complication in critically ill patients undergoing enteral nutrition. We aimed to conduct a meta-analysis to evaluate the risk factors of feeding intolerance in critically ill patients undergoing enteral nutrition, to provide insights to the clinical enteral nutrition treatment and care. Methods: Two researchers systematically searched PubMed, Medline, Web of Science, Cochrane Library, Chinanews. com, Wanfang and Weipu databases about the studies on the risk factors of feeding intolerance in severe patients with enteral nutrition up to August 15, 2023. Literature screening, data extraction and quality evaluation were carried out independently by two researchers, and Meta analysis was carried out with RevMan 5.3 software and Stata 15.0 software. Results: 18 studies involving 5564 enteral nutrition patients were included. The results of meta-analyses showed that age < 2 years old, age > 60 years old, APACHE II score ≥ 20, Hypokalemia, starting time of enteral nutrition > 72 hours, no dietary fiber, intra-abdominal pressure > 15mmHg, central venous pressure > 10cmH Conclusion: The incidence of feeding intolerance in critically ill patients undergoing enteral nutrition is high, and there are many influencing factors. Clinical medical workers should take effective preventive measures according to the risk and protective factors of patients to reduce the incidence of feeding intolerance and improve the prognosis of patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.