Evidence map›Paper›PMID 39108921›Full record

ArticleHeliyon2024

Nicotinamide riboside first alleviates symptoms but later downregulates dopamine metabolism in proteasome inhibition mouse model of Parkinson's disease.

Giorgio Turconi, Farhan Alam, Tanima SenGupta, Sini Pirnes-Karhu, Soophie Olfat, Mark S Schmidt, Kärt Mätlik, Ana Montaño-Rodriguez, Vladimir Heiskanen, Daniel Garton and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Redox Molecules in Aging and Neurodegenerative Disorders.International journal of molecular sciences · 2026
    Review
  2. Restoring NADFrontiers in nutrition · 2026
    Review
  3. Review
  4. The role of NADnpj metabolic health and disease · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Giorgio TurconiDepartment of Pharmacology, Faculty of Medicine, Haartmaninkatu 8, 00014, University of Helsinki, Helsinki, Finland.
Farhan AlamResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, 00290, Finland.
Tanima SenGuptaDepartment of Microbiology, Oslo University Hospital PO Box 0424 Oslo, Norway and University of Oslo, The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway.
Sini Pirnes-KarhuResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, 00290, Finland.
Soophie OlfatDepartment of Pharmacology, Faculty of Medicine, Haartmaninkatu 8, 00014, University of Helsinki, Helsinki, Finland.
Mark S SchmidtDepartment of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Kärt MätlikDepartment of Pharmacology, Faculty of Medicine, Haartmaninkatu 8, 00014, University of Helsinki, Helsinki, Finland.
Ana Montaño-RodriguezDepartment of Pharmacology, Faculty of Medicine, Haartmaninkatu 8, 00014, University of Helsinki, Helsinki, Finland.
Vladimir HeiskanenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, 00290, Finland.
Daniel GartonDepartment of Pharmacology, Faculty of Medicine, Haartmaninkatu 8, 00014, University of Helsinki, Helsinki, Finland.
Petteri T PiepponenDivision of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Viikinkaari 5E, 00014, University of Helsinki, Helsinki, Finland.
Charles BrennerDepartment of Diabetes & Cancer Metabolism, City of Hope National Medical Center, Duarte, CA, USA.
Carina I HolmbergMedicum, Department of Biochemistry and Developmental Biology, Faculty of Medicine, University of Helsinki, 00290, Helsinki, Finland.
Hilde NilsenDepartment of Microbiology, Oslo University Hospital PO Box 0424 Oslo, Norway and University of Oslo, The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway.
Eija PirinenResearch Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, 00290, Finland.
Jaan-Olle AndressooDepartment of Pharmacology, Faculty of Medicine, Haartmaninkatu 8, 00014, University of Helsinki, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is associated with a reduction in 26/20S proteasome and mitochondrial function and depletion of dopamine. Activation of mitochondrial function with the NAD

Indexed as

DopamineMitochondrial activationNicotinamide ribosideParkinson's diseaseProteastasis failure

Identifiers

PMID39108921
PMCPMC11301377

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.