Evidence map›Paper›PMID 39108977›Full record

ArticleCase reports in pediatrics2024

SARS-CoV-2-Triggered Hemophagocytic Lymphohistiocytosis with Complications of Posterior Reversible Encephalopathy Syndrome.

Ross M Perry, Scott D Casey, Alex Q Lee, Sylvia P Bowditch, Mary A Rasmussen, Viyeka Sethi, Arun R Panigrahi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ross M PerrySchool of Medicine University of California, Davis, Sacramento, California, USA.ORCID https://orcid.org/0000-0002-8186-8148
Scott D CaseyDepartment of Emergency Medicine University of California, Davis, Sacramento, California, USA.ORCID https://orcid.org/0000-0001-6733-2155
Alex Q LeeSchool of Medicine University of California, Davis, Sacramento, California, USA.
Sylvia P BowditchDepartment of Pediatrics University of California, Davis, Sacramento, California, USA.
Mary A RasmussenDepartment of Pediatrics University of California, Davis, Sacramento, California, USA.
Viyeka SethiDepartment of Pediatric Critical Care Medicine University of California, Davis, Sacramento, California, USA.
Arun R PanigrahiDepartment of Pediatric Hematology and Oncology University of California, Davis, Sacramento, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this article, we describe a novel case of SARS-CoV-2-associated-hemophagocytic lymphohistiocytosis (HLH) complicated by posterior reversible encephalopathy syndrome (PRES). Initially diagnosed with multisystem inflammatory response in children (MIS-C), the patient received a large corticosteroid dose days before the onset of neurological symptoms. After developing PRES, the patient was treated with antihypertensives, antiepileptics, dexamethasone, and anakinra, leading to neurologic normalization. We propose that given the challenging diagnostic picture of PRES developing in patients with HLH or MIS-C, institutionalized standards for blood pressure management during corticosteroid induction may significantly improve outcomes in patients being treated for hyperinflammatory syndromes who develop neurological symptoms.

Identifiers

PMID39108977
PMCPMC11303060

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.