Evidence map›Paper›PMID 39108992›Full record

ArticleMediators of inflammation2024

Anti-Inflammatory and Antioxidant Properties of a New Mixture of Vitamin C, Collagen Peptides, Resveratrol, and Astaxanthin in Tenocytes: Molecular Basis for Future Applications in Tendinopathies.

Monica Marzagalli, Stefania Battaglia, Michela Raimondi, Fabrizio Fontana, Marco Cozzi, Francesca R Ranieri, Roberto Sacchi, Valeria Curti, Patrizia Limonta

Abstract read
In one paragraph

Article in Mediators of inflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Monica MarzagalliDepartment of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti" University of Milano, Milano 20133, Italy.ORCID https://orcid.org/0000-0001-7684-606X
Stefania BattagliaR&D Department Kolinpharma S.p.A., Lainate 20045, Italy.ORCID https://orcid.org/0009-0006-1390-334X
Michela RaimondiDepartment of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti" University of Milano, Milano 20133, Italy.ORCID https://orcid.org/0000-0002-2965-509X
Fabrizio FontanaDepartment of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti" University of Milano, Milano 20133, Italy.ORCID https://orcid.org/0000-0002-9148-0884
Marco CozziR&D Department Kolinpharma S.p.A., Lainate 20045, Italy.ORCID https://orcid.org/0009-0007-6603-8756
Francesca R RanieriR&D Department Kolinpharma S.p.A., Lainate 20045, Italy.ORCID https://orcid.org/0009-0002-0050-296X
Roberto SacchiDepartment of Earth and Environmental Sciences University of Pavia, Pavia 27100, Italy.ORCID https://orcid.org/0000-0002-6199-0074
Valeria CurtiR&D Department Kolinpharma S.p.A., Lainate 20045, Italy.ORCID https://orcid.org/0009-0001-5051-2106
Patrizia LimontaDepartment of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti" University of Milano, Milano 20133, Italy.ORCID https://orcid.org/0000-0001-7028-3008

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendinopathy is one of the most frequent musculoskeletal disorders characterized by sustained tissue inflammation and oxidative stress, accompanied by extracellular matrix remodeling. Patients suffering from this pathology frequently experience pain, swelling, stiffness, and muscle weakness. Current pharmacological interventions are based on nonsteroidal anti-inflammatory drugs; however, the effectiveness of these strategies remains ambiguous. Accumulating evidence supports that oral supplementation of natural compounds can provide preventive, and possibly curative, effects. Vitamin C (Vit C), collagen peptides (Coll), resveratrol (Res), and astaxanthin (Asx) were reported to be endowed with potential beneficial effects based on their anti-inflammatory and antioxidant activities. Here, we analyzed the efficacy of a novel combination of these compounds (Mix) in counteracting proinflammatory (IL-1

Indexed as

Anti-Inflammatory AgentsAntioxidantsAscorbic AcidCollagenResveratrolTendinopathyTenocytesXanthophyllsCells, CulturedHumansHydrogen PeroxideInterleukin-1betaNF-kappa BOxidative StressPeptidesReactive Oxygen SpeciesAnti-Inflammatory AgentsAntioxidantsAscorbic AcidastaxanthineCollagenHydrogen PeroxideInterleukin-1betaNF-kappa BPeptidesReactive Oxygen SpeciesResveratrolStilbenesXanthophylls

Identifiers

PMID39108992
PMCPMC11303056

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.