Evidence map›Paper›PMID 39109799›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2025

Effects of Exercise on Bone Marrow Adipose Tissue in Children With Overweight/Obesity: Role of Liver Fat.

Idoia Labayen, Cristina Cadenas-Sánchez, Fernando Idoate, Luis Gracia-Marco, María Medrano, Víctor Manuel Alfaro-Magallanes, Juan M A Alcantara, Beatriz Rodríguez-Vigil, Maddi Osés, Francisco B Ortega and 2 more

Abstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Idoia LabayenInstitute for Sustainability & Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre, 31006 Pamplona, Navarre, Spain.ORCID 0000-0002-4334-3287
Cristina Cadenas-SánchezInstitute for Sustainability & Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre, 31006 Pamplona, Navarre, Spain.
Fernando IdoateRadiology Department, Mutua Navarra, Department of Health Sciences, Public University of Navarre, 31012 Pamplona, Navarre, Spain.
Luis Gracia-MarcoCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.ORCID 0000-0002-4020-0256
María MedranoInstitute for Sustainability & Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre, 31006 Pamplona, Navarre, Spain.
Víctor Manuel Alfaro-MagallanesInstitute for Sustainability & Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre, 31006 Pamplona, Navarre, Spain.
Juan M A AlcantaraInstitute for Sustainability & Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre, 31006 Pamplona, Navarre, Spain.
Beatriz Rodríguez-VigilDepartment of Magnetic Resonance Imaging, University Hospital of Araba (HUA), Osakidetza Basque Health Service, Osatek, Bioaraba Health Research Institute, 01004 Vitoria-Gasteiz, Alava, Spain.
Maddi OsésInstitute for Sustainability & Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre, 31006 Pamplona, Navarre, Spain.
Francisco B OrtegaCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Jonatan R RuizCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Rafael CabezaDepartment of Electrical, Electronic and Communications Engineering, Smart Cities Institute, Public University of Navarre, 31006 Pamplona, Spain.

Funding

European Regional Development Funds (ERDF) ERDF 2014-2020European UnionEuropean Union Next Generation FJC2020-044453-IJ.M.A.A. MCIN/AEI/10.13039/501100011033Margarita Salas RCMS-22-KIAO1C-24-GSMTDXRegional Government of Navarra's Department of Economic Development 0011-1365-2019-000152Spanish Ministry of Economy and Competitiveness BES-2017-080770Spanish Ministry of Health's PI13/01335Spanish Ministry of Science and Innovation FJC2018-037925-ISpanish Ministry of the Economy Industry and Competitiveness DEP2016-78377-R
6 · The paper itself

Abstract

contextExercise reduces adiposity, but its influence on bone marrow fat fraction (BMFF) is unknown; nor is it known whether a reduction in liver fat content mediates this reduction.

objectivesThis work aimed to determine whether incorporating exercise into a lifestyle program reduces the lumbar spine (LS) BMFF and to investigate whether changes in liver fat mediate any such effect.

methodsAncillary analysis of a 2-arm, parallel, nonrandomized clinical trial was conducted at primary care centers in Vitoria-Gasteiz, Spain. A total of 116 children with overweight/obesity were assigned to a 22-week family-based lifestyle program (control group [n = 57]) or the same program plus an exercise intervention (exercise group [n = 59]). The compared interventions consisted of a family-based lifestyle program (two 90-minute sessions/month) and the same program plus supervised exercise (three 90-minute sessions/week). The primary outcome examined was the change in LS-BMFF between baseline and 22 weeks, as estimated by magnetic resonance imaging. The effect of changes in hepatic fat on LS-BMFF were also recorded.

resultsMean weight loss difference between groups was 1.4 ± 0.5 kg in favor of the exercise group. Only the children in the exercise group experienced a reduction in LS-BMFF (effect size [Cohen d] -0.42; CI, -0.86 to -0.01). Importantly, 40.9% of the reductions in LS-BMFF were mediated by changes in percentage hepatic fat (indirect effect: β=-0.104; 95% CI, -0.213 to -0.019). The effect of changes in hepatic fat on LS-BMFF was independent of weight loss.

conclusionThe addition of exercise to a family-based lifestyle program designed to reduce cardiometabolic risk improves bone health by reducing LS-BMFF in children with overweight or obesity. This beneficial effect on bone marrow appears to be mediated by reductions in liver fat.

Indexed as

Adipose TissueBone MarrowExerciseExercise TherapyLiverOverweightPediatric ObesityAdiposityAdolescentChildFemaleHumansLife StyleMagnetic Resonance ImagingMaleNon-Randomized Controlled Trials as Topicbone healthfatty liverlifestyleMAFLDMASLDNAFLDobesityyouth

Identifiers

PMID39109799
PMCPMC11834710

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.