Evidence map›Paper›PMID 39109999›Full record

ArticleeLife2024

Syntaxin-6 delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates.

Daljit Sangar, Elizabeth Hill, Kezia Jack, Mark Batchelor, Beenaben Mistry, Juan M Ribes, Graham S Jackson, Simon Mead, Jan Bieschke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daljit SangarMRC Prion Unit at UCL, Institute of Prion Diseases, London, United Kingdom.
Elizabeth HillMRC Prion Unit at UCL, Institute of Prion Diseases, London, United Kingdom.
Kezia JackMRC Prion Unit at UCL, Institute of Prion Diseases, London, United Kingdom.
Mark BatchelorMRC Prion Unit at UCL, Institute of Prion Diseases, London, United Kingdom.ORCID https://orcid.org/0000-0001-6847-5131
Beenaben MistryMRC Prion Unit at UCL, Institute of Prion Diseases, London, United Kingdom.
Juan M RibesMRC Prion Unit at UCL, Institute of Prion Diseases, London, United Kingdom.
Graham S JacksonMRC Prion Unit at UCL, Institute of Prion Diseases, London, United Kingdom.
Simon MeadMRC Prion Unit at UCL, Institute of Prion Diseases, London, United Kingdom.
Jan BieschkeMRC Prion Unit at UCL, Institute of Prion Diseases, London, United Kingdom.ORCID https://orcid.org/0000-0002-3485-9767

Funding

TEMPLATED CONVERSION OF TRANSMISSIBLE PROTEINS IN NEUROMUSCULAR DISEASER21NS101588 · NINDS · WASHINGTON UNIVERSITY · PI WEIHL, CONRAD C · 2018 to 2019
$419k
Medical Research Council MC_UU_00024/6Medical Research Council MRC Prion Unit Graduate ProgrammeNINDS NIH HHS 1R21NS101588-01A1NINDS NIH HHS R21 NS101588
6 · The paper itself

Abstract

Prions replicate via the autocatalytic conversion of cellular prion protein (PrP

Indexed as

Qa-SNARE ProteinsAnimalsCreutzfeldt-Jakob SyndromeHumansMiceNeuronsPrion ProteinsProtein AggregatesPrion ProteinsProtein AggregatesQa-SNARE Proteinsaggregationamyloidbiochemistrychaperonechemical biologyE. colimouseprionsyntaxintoxicity

Identifiers

PMID39109999
PMCPMC11377041

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.