Evidence map›Paper›PMID 39110372›Full record

ReviewCurrent nutrition reports2024

The Role of Short-Chain Fatty Acids in Myocardial Ischemia-Reperfusion Injury.

Xunxun Wang, Yalan Dong, Renyin Huang, Fang Wang, Junke Xie, Hui Liu, Yan Wang, Yi Wang, Shanshan Luo, Desheng Hu

Abstract readReview
In one paragraph

Review in Current nutrition reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Polysaccharides from the Cherry Peel ofFoods (Basel, Switzerland) · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xunxun WangDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Jingshan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yalan DongDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Jingshan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Renyin HuangJingshan Union Hospital, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
Fang WangJingshan Union Hospital, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
Junke XieJingshan Union Hospital, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
Hui LiuJingshan Union Hospital, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
Yan WangJingshan Union Hospital, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
Yi WangJingshan Union Hospital, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
Shanshan LuoInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Desheng HuDepartment of Integrated Traditional Chinese and Western Medicine, Union Hospital, Jingshan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. desheng.hu@hust.edu.cn.

Funding

National Natural Science Foundation of China 82274317National Natural Science Foundation of China 82305194Postdoctoral Science Foundation of China 2023M731222
6 · The paper itself

Abstract

purpose of reviewThis study aims to review the effects of short-chain fatty acids (SCFAs) in regulating the myocardial ischemia-reperfusion injury (MIRI). RECENT

findingsCoronary heart disease (CHD) is a well-known leading cause of death and disability worldwide. Cardiac substrate metabolism plays the determinant role in assessing the severity of heart injury due to the abruptly shifted energy production during the MIRI. Fatty acids are the main energy fuels for the heart, which are classified into long-, medium- and short chain fatty acids by the length of carbon chain. SCFAs are the main metabolites derived from the anaerobic bacterial fermentation of fiber-rich diets, which are shown to play a protective role in cerebrovascular disease previously. Meanwhile, accumulating evidences suggest that SCFAs can also play a crucial role in cardiac energy metabolism. Results of various studies revealed the cardioprotective effects of SCFAs by displaying anti-inflammatory and anti-ferroptotic function, connecting gut-brain neural circuit and regulating the intestinal flora.

Indexed as

Energy MetabolismFatty Acids, VolatileMyocardial Reperfusion InjuryAnimalsGastrointestinal MicrobiomeHumansMyocardiumFatty Acids, VolatileCardiovascular diseaseMyocardial ischemia-reperfusion injuryMyocardial metabolismShort-chain fatty acids

Identifiers

PMID39110372
PMCPMC11489193

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.