ArticleNeurobiology of aging2024
Multimodal investigation of neuropathology and neurometabolites in mild cognitive impairment and late-life depression with
Abstract read
In one paragraph
Article in Neurobiology of aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neurometabolics of the anterior cingulate cortex (ACC) in major depressive disorder (MDD): A systematic review and meta-analysis.NeuroImage. Clinical · 2026Pooled it
- Glutamatergic and GABAergic metabolite levels in Alzheimer's disease: a systematic review and meta-analysis.BMC neurology · 2025Pooled it
- The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion-Tensor-Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review.Journal of magnetic resonance imaging : JMRI · 2026Review
- Lactate and lactylation in neuropsychiatric disorders: a comprehensive review.Molecular biology reports · 2026Review
- Multimodal neuroimaging discrimination of Alzheimer's disease, mild cognitive impairment, and late-life depression using electroencephalography and functional near-infrared spectroscopy: integrating electrophysiological and hemodynamic biomarkers.Frontiers in aging neuroscience · 2026Article
- Multi-Index Brain Function-Cognition Correlation in Amnestic Mild Cognitive Impairment: A Resting-State fMRI Study.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Christopher W Davies-JenkinsThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Clifford I WorkmanDivision of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kathleen E HupfeldThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Helge J ZöllnerThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Jeannie-Marie LeoutsakosDivision of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Michael A KrautThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Peter B BarkerThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Gwenn S SmithDivision of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Division of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: gsmith95@jhmi.edu.
Georg OeltzschnerThe Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Funding
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Peter CM Van Zijl · 2021 to 2026
$9.9MLongitudinal Molecular Imaging of Neuropathology and Serotonin in Mild Cognitive ImpairmentR01AG059390 · NIA · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S · 2018 to 2022
$4.8MGeriatric Depression: PET Studies of Pathophysiology and Treatment ResponseR01MH086881 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S · 2010 to 2013
$2.7MLongitudinal imaging of neuropsychiatric symptoms in mild cognitive impairmentR01AG041633 · NIA · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S · 2011 to 2015
$2.6MPET Studies of Serotonin and Amyloid in MCIR01AG038893 · NIA · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S · 2011 to 2014
$2.4MSerotonin Modulation in Geriatric DepressionR01MH064823 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SMITH, GWENN S. · 2003 to 2006
$1.9MTowards a comprehensive neurometabolic profile in patients with mild cognitive impairment.R00AG062230 · NIA · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2021 to 2023
$735kGeneral Linear Modeling For Magnetic Resonance SpectroscopyR21EB033516 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2022 to 2024
$670kCortical Inhibition and Mobility in Older AdultsK00AG068440 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUPFELD, KATHLEEN ELIZABETH · 2022 to 2024
$222kTowards a comprehensive neurometabolic profile in patients with mild cognitive impairment.K99AG062230 · NIA · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2019 to 2020
$171kNCATS NIH HHS UL1 TR001079NIA NIH HHS K00 AG068440NIA NIH HHS K99 AG062230NIA NIH HHS R00 AG062230NIA NIH HHS R01 AG038893NIA NIH HHS R01 AG041633NIA NIH HHS R01 AG059390NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R21 EB033516NIMH NIH HHS R01 MH064823NIMH NIH HHS R01 MH086881
Abstract
Positron emission tomography (PET) and magnetic resonance spectroscopy (
Indexed as
Amyloid beta-PeptidesCognitive DysfunctionDepressionPositron-Emission TomographyAgedAged, 80 and overAlzheimer DiseaseAniline CompoundsFemaleGyrus CinguliHumansMagnetic Resonance SpectroscopyMaleMiddle AgedMultimodal ImagingThiazoles2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAmyloid beta-PeptidesAniline CompoundsThiazolesbeta-amyloidGABAglutamatelate-life depressionmagnetic resonance spectroscopymild cognitive impairment
Identifiers
What Socratic holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.