Evidence map›Paper›PMID 39112771›Full record

ArticleActa pharmacologica Sinica2025

Esculetin facilitates post-stroke rehabilitation by inhibiting CKLF1-mediated neutrophil infiltration.

Jia-Qi He, Ruo-Lan Yuan, Yu-Tong Jiang, Ye Peng, Jun-Rui Ye, Sha-Sha Wang, Li-Qing Li, Yuan Ruan, Pei-Yi Li, Xu Yan and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jia-Qi HeTianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Ruo-Lan YuanTianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Yu-Tong JiangTianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Ye PengState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medical & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Jun-Rui YeState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medical & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Sha-Sha WangState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medical & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Li-Qing LiState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medical & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Yuan RuanTianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Pei-Yi LiTianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Xu YanState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medical & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
Wen-Bin HeNational International Joint Research Center for Molecular Chinese Medicine, Shanxi University of Chinese Medicine, Taiyuan, 030024, China.
Gang LiGraduate school, Inner Mongolian Medical University, Hohhot, 010110, China.
Shi-Feng ChuState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medical & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. chushifeng@imm.ac.cn.
Zhao ZhangState Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medical & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. zhangzhao@imm.ac.cn.
Nai-Hong ChenTianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. chennh@imm.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esculetin (ESC) is a coumarin-derived phytochemical prevalent in traditional Chinese medicine that exhibits anti-acute ischemic stroke activities. Our previous studies demonstrate that CKLF1 is a potential anti-stroke target for coumarin-derived compound. In this study we investigated whether CKLF1 was involved in the neuroprotective effects of ESC against photothrombotic stroke in mice. The mice were treated with ESC (20, 40 or 80 mg·kg

Indexed as

Mice, Inbred C57BLNeuroprotective AgentsNeutrophil InfiltrationUmbelliferonesAnimalsChemokinesMaleMARVEL Domain-Containing ProteinsMiceStrokeChemokinesCKLF1 protein, mouseesculetinMARVEL Domain-Containing ProteinsNeuroprotective AgentsUmbelliferonesCCR5CKLF1coumarinesculetinischemic strokeneutrophil infiltration

Identifiers

PMID39112771
PMCPMC11697434

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.