Evidence map›Paper›PMID 39113589›Full record

ReviewJournal of extracellular vesicles2024

Potential of extracellular vesicles in the pathogenesis, diagnosis and therapy for parasitic diseases.

Ana Acacia Sá Pinheiro, Ana Claudia Torrecilhas, Bruno Solano de Freitas Souza, Fernanda Ferreira Cruz, Herbert Leonel de Matos Guedes, Tadeu Diniz Ramos, Miqueias Lopes-Pacheco, Celso Caruso-Neves, Patricia R M Rocco

Abstract readReview
In one paragraph

Review in Journal of extracellular vesicles, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Placental Barrier Breakdown Induced byInternational journal of molecular sciences · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Protein dysregulation duringFrontiers in immunology · 2025
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ana Acacia Sá PinheiroInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-3894-1645
Ana Claudia TorrecilhasDepartamento de Ciências Farmacêuticas, Diadema Campus, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo (UNIFESP), Diadema, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-5724-2199
Bruno Solano de Freitas SouzaCenter for Biotechnology and Cell Therapy, São Rafael Hospital, Salvador, Brazil.ORCID https://orcid.org/0000-0003-3771-0439
Fernanda Ferreira CruzInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-9443-3648
Herbert Leonel de Matos GuedesInstituto de Microbiologia Paulo de Goés (IMPG), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-3819-3069
Tadeu Diniz RamosInstituto de Microbiologia Paulo de Goés (IMPG), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-8523-4361
Miqueias Lopes-PachecoInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-7444-9359
Celso Caruso-NevesInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-2415-7753
Patricia R M RoccoInstituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-1412-7136

Funding

Brazilian Council for Scientific and Technological Development (CNPq), Brazil 408124/2021-0Rio de Janeiro State Research Foundation E-26/210.181/2020 [PRMR]
6 · The paper itself

Abstract

Parasitic diseases have a significant impact on human and animal health, representing a major hazard to the public and causing economic and health damage worldwide. Extracellular vesicles (EVs) have long been recognized as diagnostic and therapeutic tools but are now also known to be implicated in the natural history of parasitic diseases and host immune response modulation. Studies have shown that EVs play a role in parasitic disease development by interacting with parasites and communicating with other types of cells. This review highlights the most recent research on EVs and their role in several aspects of parasite-host interactions in five key parasitic diseases: Chagas disease, malaria, toxoplasmosis, leishmaniasis and helminthiases. We also discuss the potential use of EVs as diagnostic tools or treatment options for these infectious diseases.

Indexed as

Extracellular VesiclesHost-Parasite InteractionsParasitic DiseasesAnimalsChagas DiseaseHumansChagas Diseaseextracellular vesicleshelminthiasisleishmaniasismalariatoxoplasmosis

Identifiers

PMID39113589
PMCPMC11306921

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.