Evidence map›Paper›PMID 39114545›Full record

ArticleJournal of Alzheimer's disease reports2024

Sim K Singhrao, Claudia Consoli, Sarah R Dennison, Shalini Kanagasingam, Richard Welbury

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Lipopolysaccharides fromJournal of Alzheimer's disease : JAD · 2025
    Article
  2. Alzheimer's Disease andLife (Basel, Switzerland) · 2025
    Review
  3. Identifying Alzheimer's disease genes in apolipoprotein EJournal of Alzheimer's disease reports
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sim K SinghraoSchool of Medicine and Dentistry, University of Central Lancashire, Preston, UK.
Claudia ConsoliCentral Biotechnology Services, College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK.
Sarah R DennisonSchool of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, UK.
Shalini KanagasingamSchool of Medicine and Dentistry, University of Central Lancashire, Preston, UK.
Richard WelburySchool of Medicine and Dentistry, University of Central Lancashire, Preston, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Glycogen synthase-3 kinase (GSK3) is one of the major contributors of tau hyperphosphorylation linked to neurofibrillary tangles in Alzheimer's disease (AD). Objective: To determine a mechanism of GSK-3β activation by two periodontal bacteria consistently confirmed in AD autopsied brains. Methods: Results: qPCR demonstrated that GSK-3β gene was overexpressed in IMR-32 cells treated with Pg.LPS with a 2.09-fold change ( Conclusions: Exposure to various bacterial factors upregulated the gene expression of GSK-3β. Western blotting for GSK-3β confirmed the presence of the cleaved fragment by Pg.LPS (37 kDa band

Indexed as

Actinomyces naeslundiiAlzheimer’s diseaseglycogen synthase-3 kinaseinflammationLPSPorphyromonas gingivalis

Identifiers

PMID39114545
PMCPMC11305843

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.