Evidence map›Paper›PMID 39115053›Full record

ArticleMolecular oncology2025

Loss of Lkb1 cooperates with Braf

Kimberley McGrail, Elena González-Sánchez, Paula Granado-Martínez, Roberto Orsenigo, Yuxin Ding, Berta Ferrer, Javier Hernández-Losa, Iván Ortega, Juan Martín-Caballero, Eva Muñoz-Couselo and 2 more

Abstract read
In one paragraph

Article in Molecular oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kimberley McGrailBiomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall d'Hebron Research Institute VHIR, Vall d'Hebron Hospital-UAB, Barcelona, Spain.
Elena González-SánchezBiomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall d'Hebron Research Institute VHIR, Vall d'Hebron Hospital-UAB, Barcelona, Spain.
Paula Granado-MartínezBiomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall d'Hebron Research Institute VHIR, Vall d'Hebron Hospital-UAB, Barcelona, Spain.
Roberto OrsenigoBiomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall d'Hebron Research Institute VHIR, Vall d'Hebron Hospital-UAB, Barcelona, Spain.
Yuxin DingBiomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall d'Hebron Research Institute VHIR, Vall d'Hebron Hospital-UAB, Barcelona, Spain.
Berta FerrerAnatomy Pathology Department, Vall d'Hebron Hospital-UAB, Barcelona, Spain.
Javier Hernández-LosaAnatomy Pathology Department, Vall d'Hebron Hospital-UAB, Barcelona, Spain.
Iván OrtegaAnimal Laboratory Unit, Biomedical Research Park of Barcelona-PRBB, Spain.
Juan Martín-CaballeroAnimal Laboratory Unit, Biomedical Research Park of Barcelona-PRBB, Spain.
Eva Muñoz-CouseloClinical Oncology Program, Vall d'Hebron Institute of Oncology (VHIO), Vall d'Hebron Hospital-UAB, Barcelona, Spain.
Vicente García-PatosDermatology Department, Vall d'Hebron Hospital-UAB, Barcelona, Spain.
Juan A RecioBiomedical Research in Melanoma-Animal Models and Cancer Laboratory, Vall d'Hebron Research Institute VHIR, Vall d'Hebron Hospital-UAB, Barcelona, Spain.ORCID https://orcid.org/0000-0002-7320-3832

Funding

Agència de Gestió d'Ajuts Universitaris i de Recerca 2021-SGR00653European UnionFundación Científica Asociación Española Contra el Cáncer AECC-GCB15152978SOENFundacion Ramón ArecesInstitute of Health Carlos III-Euronanomed II AC16/00019-Fondos FEDER European UnionInstituto de Salud Carlos III PI17/00043-Fondos FEDERInstituto de Salud Carlos III PI20/0384-Fondos FEDERInstituto de Salud Carlos III PI23/00428-Fondos FEDER
6 · The paper itself

Abstract

The mechanisms that work alongside BRAF

Indexed as

Cell DedifferentiationMelanomaNeuronsProtein Serine-Threonine KinasesProto-Oncogene Proteins B-rafUltraviolet RaysAMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesAnimalsDNA RepairHumansMelanocytesMiceAMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesBraf protein, mouseProtein Serine-Threonine KinasesProto-Oncogene Proteins B-rafStk11 protein, mouseBRAFV600ELKB1melanomaneural crest likeultraviolet radiation

Identifiers

PMID39115053
PMCPMC11792986

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.