Evidence map›Paper›PMID 39115641›Full record

ArticleGeroScience2025

Non-invasive myocardial work as an independent predictor of postprocedural NT-proBNP in elderly patients undergoing transcatheter aortic valve replacement.

Zsuzsanna Ladányi, Tímea Bálint, Alexandra Fábián, Adrienn Ujvári, Tímea Katalin Turschl, Dávid Nagy, Éva Straub, Csaba Fejér, Endre Zima, Astrid Apor and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Zsuzsanna Ladányi *Heart and Vascular Center, Semmelweis University, Budapest, Hungary. lazsuzs9@gmail.com.ORCID 0000-0002-6258-1985
Tímea Bálint *Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Alexandra FábiánHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Adrienn UjváriHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Tímea Katalin TurschlHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Dávid NagyHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Éva StraubHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Csaba FejérHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Endre ZimaHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Astrid AporHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Anikó Ilona NagyHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Tímea SzigethiHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Roland PappHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Levente MolnárHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Attila KovácsHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Mihály Ruppert *Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Bálint Károly Lakatos *Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Béla Merkely *Heart and Vascular Center, Semmelweis University, Budapest, Hungary. merkely.study@kardio.sote.hu.ORCID 0000-0001-6514-0723

Funding

European Union RRF-2.3.1-21-2022-00003Innovációs és Technológiai Minisztérium TKP2021-EGA-23Innovációs és Technológiai Minisztérium ÚNKP-23-3-I-SE-64Innovációs és Technológiai Minisztérium ÚNKP-23-4-II-SE-37National Research, Development and Innovation Office K-146732 OTKA
6 · The paper itself

Abstract

Aortic stenosis has become the most prevalent valvular disease with increasing life expectancy and the ageing of the population, representing a significant clinical burden for health care providers. Its treatment has been revolutionized by transcatheter aortic valve replacement (TAVR) as a safe and minimally invasive option for elderly patients. Left ventricular (LV) functional measurement is of particular importance before TAVR, however, increased afterload significantly influences the conventional echocardiographic parameters. Non-invasive myocardial work examines myocardial deformation in the context of instantaneous LV pressure, thus, it might be a more reliable measure of LV function. Accordingly, we aimed to study non-invasive myocardial work and its relationship with functional outcome following TAVR.We enrolled 90 TAVR candidates (80 [75-84] years; 44% female). Using echocardiography, we quantified ejection fraction (EF), global longitudinal strain (GLS), global myocardial work index (GWI) and global constructive work (GCW) before and 12 months after the procedure. Serum NT-proBNP levels were also measured. EF did not change (52.6 ± 13.1 vs. 54.2 ± 10.5%; p = 0.199), while GLS increased (-13.5 ± 4.6 vs. -15.2 ± 3.8%; p < 0.001). GWI decreased (1913 ± 799 vs. 1654 ± 613 mmHg%; p < 0.001) and so did GCW (2365 ± 851 vs. 2177 ± 652 mmHg%; p = 0.018). History of atrial fibrillation (AF) (β = 0.349) and preprocedural GCW (β = -0.238) were independent predictors of postprocedural NT-proBNP (p < 0.001).GLS, GWI and GCW changed after TAVR while there was no alteration in EF. The preprocedural GCW and history of AF were independent predictors of postprocedural NT-proBNP. Accordingly, myocardial work indices may help patient selection and the prediction of the functional outcome in this population.

Indexed as

Aortic Valve StenosisNatriuretic Peptide, BrainPeptide FragmentsTranscatheter Aortic Valve ReplacementAgedAged, 80 and overBiomarkersEchocardiographyFemaleHumansMaleStroke VolumeVentricular Function, LeftBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Aortic stenosisEchocardiographyMyocardial workN-terminal pro-beta natriuretic peptideTranscatheter aortic valve replacementValvular disease

Identifiers

PMID39115641
PMCPMC12181568

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.