Evidence map›Paper›PMID 39116228›Full record

ArticleScience (New York, N.Y.)2024

PI4P-mediated solid-like Merlin condensates orchestrate Hippo pathway regulation.

Pengfei Guo, Bing Li, Wei Dong, Huabin Zhou, Li Wang, Ting Su, Christopher Carl, Yonggang Zheng, Yang Hong, Hua Deng and 1 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Article
  3. Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harbor perspectives in biology · 2026
    Article
  4. Redox-Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Article
  6. Article
  7. Mechanobiology of the Hippo-YAP Signaling Network.Cold Spring Harbor perspectives in biology · 2026
    Article
  8. Article
  9. Distinct impact of PI(4)P flux on PI(4,5)PProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Targeting the Hippo pathway in cancer.Nature reviews. Drug discovery · 2025
    Review
  14. Biomolecular condensates in Hippo pathway regulation.Journal of Zhejiang University. Science. B · 2025
    Review
  15. Review
  16. Micropipette aspiration reveals differential RNA-dependent viscoelasticity of nucleolar subcompartments.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pengfei GuoDepartment of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-4618-6803
Bing LiDepartment of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Wei DongDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0001-5519-4859
Huabin ZhouDepartment of Biophysics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-7788-0806
Li WangDepartment of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Ting SuDepartment of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Christopher CarlDepartment of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Yonggang ZhengDepartment of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-3326-4614
Yang HongDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-2252-0798
Hua DengDepartment of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2905-7890
Duojia PanDepartment of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-2890-4645

Funding

DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Control of Cell Number in Developing RetinaR01EY015708 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI DUOJIA PAN · 2004 to 2026
$8.8M
UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeff G McDonald · 2022 to 2026
$7.4M
Plasma Membrane Targeting and Retargeting of Polarity ProteinsR01GM121534 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HONG, YANG · 2017 to 2025
$2.5M
Request for a Nikon A1 confocal microscopeS10OD019973 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2015 to 2015
$358k
Howard Hughes Medical InstituteNEI NIH HHS R01 EY015708NIDDK NIH HHS P30 DK127984NIGMS NIH HHS R01 GM121534NIH HHS P40 OD010949NIH HHS S10 OD019973
6 · The paper itself

Abstract

Despite recent studies implicating liquid-like biomolecular condensates in diverse cellular processes, many biomolecular condensates exist in a solid-like state, and their function and regulation are less understood. We show that the tumor suppressor Merlin, an upstream regulator of the Hippo pathway, localizes to both cell junctions and medial apical cortex in

Indexed as

Biomolecular CondensatesDrosophila melanogasterDrosophila ProteinsHippo Signaling PathwayNeurofibromin 2AnimalsCell MembraneHippo KinasesIntercellular JunctionsIntracellular Signaling Peptides and ProteinsPhosphatidylinositol PhosphatesProtein Serine-Threonine KinasesDrosophila ProteinsHippo Kinaseshpo protein, DrosophilaIntracellular Signaling Peptides and Proteinsmerlin, DrosophilaNeurofibromin 2phosphatidylinositol 4-phosphatePhosphatidylinositol PhosphatesProtein Serine-Threonine Kinases

Identifiers

PMID39116228
PMCPMC11956869

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.