Evidence map›Paper›PMID 39116306›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Minimally Invasive Injectable Gel for Local Immunotherapy of Liver and Gastric Cancer.

Xinghui Si, Guofeng Ji, Sheng Ma, Zichao Huang, Taiyuan Liu, Zhiyuan Shi, Yu Zhang, Jia Li, Wantong Song, Xuesi Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Minimally Invasive Injectable Gel for Local Immunotherapy of Liver and Gastric Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xinghui SiKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Guofeng JiDepartment of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Sheng MaKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Zichao HuangKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Taiyuan LiuKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Zhiyuan ShiKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Yu ZhangKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
Jia LiDepartment of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
Wantong SongKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.ORCID 0000-0002-4564-9917
Xuesi ChenKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.

Funding

Bureau of International Cooperation Chinese Academy of Sciences 121522KYSB20200029Changchun Science and Technology Development Plan 21ZY09Jilin Province Development and Reform Commission 2023C043-4Jilin Province Science and Technology Development Plan 20220402037GHJilin Province Science and Technology Development Plan YDZJ202101ZYTS131Jilin Provincial International Cooperation Key Laboratory of Biomedical Polymers YDZJ202402077CXJDNational Natural Science Foundation of China 22105199National Natural Science Foundation of China 22222509National Natural Science Foundation of China 22375198National Natural Science Foundation of China 51833010National Natural Science Foundation of China 52103194National Natural Science Foundation of China 82203885Youth Innovation Promotion Association of Chinese Academy of Sciences 2020232
6 · The paper itself

Abstract

Local immunotherapy represents a promising solution for preventing tumor recurrence and metastasis post tumor surgical resection by eliminating residue tumor cells as well as eliciting tumor-specific immune responses. Minimally invasive surgery has become a mainstream surgical method worldwide due to its advantages of aesthetics and rapid postoperative recovery. Unfortunately, the currently reported local immunotherapy strategies are mostly designed to be used after open laparotomy, which go against the current surgical philosophy of minimally invasive therapy and is not suitable for clinical translation. Aiming at this problem, a minimally invasive injectable gel (MIGel) is herein reported loaded with immunotherapeutic agents for gastric and liver cancer postoperative treatment. The MIGel is formed by crosslinking between oxidized dextran (ODEX) and 4-arm polyethylene glycol hydroxylamine (4-arm PEG-ONH

Indexed as

ImmunotherapyLiver NeoplasmsStomach NeoplasmsAnimalsDisease Models, AnimalGelsHumansMiceMinimally Invasive Surgical ProceduresOxaliplatinGelsOxaliplatincancer immunotherapygastric cancerhydrogelsliver cancerminimally invasive injection

Identifiers

PMID39116306
PMCPMC11481255

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.