Evidence map›Paper›PMID 39118255›Full record

ArticleJournal of the National Cancer Institute2025

Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO).

Kathryn H Schmitz, Justin C Brown, Melinda L Irwin, Kim Robien, Jessica M Scott, Nathan A Berger, Bette Caan, Andrea Cercek, Tracy E Crane, Scott R Evans and 38 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
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  16. Adult obesity treatment and prevention: A trans-agency commentary on the research landscape, gaps, and future opportunities.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors.

Kathryn H SchmitzHematology and Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.ORCID 0000-0003-2400-2935
Justin C BrownDepartment of Cancer Energetics, Pennington Biomedical Research Center, Baton Rouge, LA, USA.ORCID 0000-0001-7540-4913
Melinda L IrwinDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA.
Kim RobienDepartment of Exercise and Nutrition Sciences and Department of Epidemiology, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Jessica M ScottDepartment of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA.
Nathan A BergerDepartment of Medicine, Division of Hematology and Oncology, Case Western Reserve University and Case Comprehensive Cancer Center, Cleveland, OH, USA.
Bette CaanDivision of Research, Kaiser Permanente of Northern California, Oakland, CA, USA.
Andrea CercekDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-5054-8192
Tracy E CraneDepartment of Medicine, Division of Medical Oncology, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL, USA.
Scott R EvansBiostatistics Center and Department of Biostatistics and Bioinformatics, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Jennifer A LigibelDivision of Breast Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-0633-3151
Jeffrey A MeyerhardtGastrointestinal Cancer Center, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID 0000-0002-1120-0898
Tanya Agurs-CollinsDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
Karen Basen-EngquistDepartment of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jennifer W BeaHealth Promotion Sciences, University of Arizona and University of Arizona Cancer Center, Tucson, AZ, USA.
Sheng F CaiHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Brenda CartmelDepartment of Chronic Disease Epidemiology, Yale School of Public Health, Yale University, New Haven, CT, USA.
Vernon M ChinchilliDepartment of Public Health Sciences, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Wendy Demark-WahnefriedDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0001-5241-932X
Christina M Dieli-ConwrightDivision of Population Sciences, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
Loretta DiPietroDepartment of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Shawna E DoerksenHematology and Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Sharon L EdelsteinBiostatistics Center, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Joanne ElenaDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
William EvansDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.
Leah M FerrucciDepartment of Chronic Disease Epidemiology, Yale School of Public Health and Yale Cancer Center, New Haven, CT, USA.
Julia FoldiHematology and Oncology, University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Sarah FreylersytheDepartment of Medicine, Division of Medical Oncology, University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL, USA.
Helena FurbergDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lee W JonesDepartment of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA.
Ross LevineHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chaya S MoskowitzDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cynthia OwusuDepartment of Medicine, Division of Hematology and Oncology, Case Western Reserve University, Cleveland, OH, USA.
Frank PenedoDepartments of Psychology and Medicine and Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Borsika A RabinHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.
Elena RatnerDepartment of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, New Haven, CT, USA.
Margaret RosenzweigSchool of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
Talya SalzDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Tara SanftSection of Medical Oncology, Yale University, New Haven, CT, USA.
Matthew SchlumbrechtDivision of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, Miami, FL, USA.
Guillaume SpielmannSchool of Kinesiology, Louisiana State University, Baton Rouge, LA, USA.
Cynthia A ThomsonDepartment of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Ashley H TjadenBiostatistics Center, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
Martin R WeiserDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-9577-7984
Shengping YangDepartment of Biostatistics, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Anthony F YuDepartment of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine, New York, NY, USA.
Frank M PernaDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
ENICTO Consortium

Funding

The Patient-Reported Outcomes, Community-Engagement and Language (PRO-CEL) CoreP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · 1985 to 2025
$88.4M
Yale Clinical and Translational Science AwardUL1TR001863 · YALE UNIVERSITY · 2025 to 2025
$9.9M
Trial of Exercise and Lifestyle (TEAL) in Women with Ovarian CancerU01CA271278 · YALE UNIVERSITY · 2025 to 2025
$1.3M
Dose-response of aerobic training during total neoadjuvant therapy for locally advanced rectal cancerU01CA271287 · SLOAN-KETTERING INST CAN RESEARCH · 2025 to 2025
$1.2M
TeleHealth Resistance exercise Intervention to preserve dose intensity and Vitality in Elder breast cancer patients (THRIVE)U01CA271277 · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2025 to 2025
$1.2M
ENICTO Consortium Coordinating CenterU24CA271246 · GEORGE WASHINGTON UNIVERSITY · 2025 to 2025
$1.2M
Adaptive Randomization of Aerobic Exercise During Chemotherapy in Colon CancerU01CA271279 · ADVENTHEALTH ORLANDO · 2025 to 2025
$374k
NCATS NIH HHS UL1 TR001863NCINCI NIH HHS P30 CA008748NCI NIH HHS U01 CA271277NCI NIH HHS U01 CA271278NCI NIH HHS U01 CA271279NCI NIH HHS U01CA271279-02NCI NIH HHS U01 CA271287NCI NIH HHS U24 CA271246NIH
6 · The paper itself

Abstract

Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project's distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the article includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that patients with cancer could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve relative dose intensity for a curative outcome.

Indexed as

ExerciseNeoplasmsAntineoplastic AgentsExercise TherapyFatigueHumansNational Cancer Institute (U.S.)Nutritional StatusQuality of LifeTreatment OutcomeUnited StatesAntineoplastic Agents

Identifiers

PMID39118255
PMCPMC11717426

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.