Evidence map›Paper›PMID 39118533›Full record

ArticleRegenerative medicine2024

PAX4 gene delivery improves β-cell function in human islets of Type II diabetes.

Yanqing Zhang, Keshab R Parajuli, Vivian A Fonseca, Hongju Wu

Abstract read
In one paragraph

Article in Regenerative medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yanqing ZhangSection of Endocrinology, Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave, #8553,New Orleans, LA 70112, USA.
Keshab R ParajuliSection of Endocrinology, Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave, #8553,New Orleans, LA 70112, USA.
Vivian A FonsecaSection of Endocrinology, Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave, #8553,New Orleans, LA 70112, USA.
Hongju WuSection of Endocrinology, Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave, #8553,New Orleans, LA 70112, USA.ORCID 0000-0003-0926-8655

Funding

The Human Islet Distribution Coordinating Center (UC4)UC4DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI EVANS-MOLINA, CARMELLA, NILAND, JOYCE CAROL · 2012 to 2017
$25.6M
Pax4-induced alpha-to-beta cell conversionR01DK107412 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI WU, HONGJU · 2016 to 2018
$1.0M
Division of Diabetes, Endocrinology, and Metabolic Diseases DK107412NIDDK NIH HHS R01 DK107412NIDDK NIH HHS UC4 DK098085Susan Harling Robinson Fellowship in Diabetes Research
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Diabetes Mellitus, Type 2Homeodomain ProteinsInsulinInsulin-Secreting CellsPaired Box Transcription FactorsCell SurvivalGenetic TherapyGene Transfer TechniquesHumansInsulin SecretionIslets of LangerhansHomeodomain ProteinsInsulinPaired Box Transcription FactorsPAX4 protein, humangene deliveryhuman isletsPax4transdifferentiationType II diabetesα cellsβ-cell dysfunctionβ cells

Identifiers

PMID39118533
PMCPMC11321267

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.