Observational studyCirculation. Heart failure2024
Trimethylamine
2 registry-linked trialsAbstract readObservational Study
In one paragraph
Observational study in Circulation. Heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Cardiovascular Health Study
Multi-Ethnic Study of Atherosclerosis (MESA)
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of TMAO, microRNAs, and the oral/gut microbiomes in atherosclerosis and myocardial infarction: mechanistic insights and translational opportunities.Journal of translational medicine · 2025Pooled it
- Impacts of intestinal microbiota metabolite trimethylamine N-oxide on cardiovascular disease: a bibliometric analysis.Frontiers in microbiology · 2024Pooled it
- Trimethylamine N-oxide and major adverse cardiac and cerebrovascular events: results of umbrella review and meta-analysis.Nutrition & metabolism · 2026Article
- The Gut-Heart-Kidney Axis in Heart Failure: Trimethylamine N-Oxide and Beyond-A State-of-the-Art Review.Biomedicines · 2026Review
- Choline status and related health outcomes in humans: A scoping review.Nutrition and health · 2026Article
- Gut microbial trimethylamine N-oxide generation promotes risk of atrial fibrillation via muscarinic receptor-mediated autonomic dysfunction.The Journal of clinical investigation · 2026Article
- Gut microbe-generated metabolite trimethylamine N-oxide and risk of abdominal aortic aneurysm: a cohort study.European heart journal · 2026Article
- The Gut-Heart Axis: A Microbiome-Centered Perspective on Heart Failure.International journal of molecular sciences · 2026Review
- Microbiome-Associated Drug Response Variability in Heart Failure Treatment.Life (Basel, Switzerland) · 2026Review
- New Advances in the Mechanisms and Therapeutic Strategies of Gut Microbiota in Regulating Glycolipid Metabolism to Combat Atherosclerosis.Journal of cardiovascular translational research · 2026Review
- The Importance of Liver-Lung Communication in Pulmonary Vascular Diseases.Comprehensive Physiology · 2026Review
- Untargeted Metabolomics Identifies N-Lactoyl-Amino Acids as Dose-Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes.Clinical pharmacology and therapeutics · 2026Article
- Article
- Gut Microbiota-Derived Trimethylamine N-Oxide and NT-proBNP in Heart Failure: A Critical Review of Diagnostic and Prognostic Value.Biomedicines · 2026Review
- Gastrointestinal metabolites: a potential bridge connecting gut microbiota and myocardial metabolic reprogramming in acute myocardial infarction.Frontiers in physiology · 2026Article
- Heart Failure and Cognitive Impairment Through the Lens of the Gut Microbiome: A Narrative Review.Journal of personalized medicine · 2025Review
- Trimethylamine N-Oxide Linking Gut Microbiota to Cardiocerebral Disease Is a Novel Biomarker for Stroke Subtypes With Mixed Etiology: A Prospective Cohort Study.CNS neuroscience & therapeutics · 2025Article
- From Gut to Heart: Targeting Trimethylamine N-Oxide as a Novel Strategy in Heart Failure Management.Biomolecules · 2025Review
- The Non-Traditional Cardiovascular Culprits in Chronic Kidney Disease: Mineral Imbalance and Uremic Toxin Accumulation.International journal of molecular sciences · 2025Review
- Cellular and Molecular Mechanisms Explaining the Link Between Inflammatory Bowel Disease and Heart Failure.Cells · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
W H Wilson Tang *Department of Cardiovascular and Metabolic Sciences (W.H.W.T., Z.W., X.S.L., I.N., J.A.D.D., D.M., S.L.H.), Lerner Research Institute, Cleveland Clinic, OH.
Rozenn N Lemaitre *Department of Medicine (R.N.L., P.N.J., A.F., N.S., B.M.P.), University of Washington, Seattle.ORCID 0000-0002-7038-1844
Paul N JensenDepartment of Medicine (R.N.L., P.N.J., A.F., N.S., B.M.P.), University of Washington, Seattle.ORCID 0000-0001-5836-821X
Meng WangFriedman School of Nutrition Science and Policy, Tufts University, Boston, MA (M.W.).ORCID 0000-0001-8345-9180
Zeneng WangDepartment of Cardiovascular and Metabolic Sciences (W.H.W.T., Z.W., X.S.L., I.N., J.A.D.D., D.M., S.L.H.), Lerner Research Institute, Cleveland Clinic, OH.ORCID 0000-0002-6455-8228
Xinmin S LiDepartment of Cardiovascular and Metabolic Sciences (W.H.W.T., Z.W., X.S.L., I.N., J.A.D.D., D.M., S.L.H.), Lerner Research Institute, Cleveland Clinic, OH.ORCID 0000-0003-4946-4271
Ina NemetDepartment of Cardiovascular and Metabolic Sciences (W.H.W.T., Z.W., X.S.L., I.N., J.A.D.D., D.M., S.L.H.), Lerner Research Institute, Cleveland Clinic, OH.ORCID 0000-0002-0657-7121
Yujin LeeDepartment of Food and Nutrition, Myongji University, Yongin, South Korea (Y.L.).ORCID 0000-0002-6948-2525
Heidi T M LaiDepartment of Primary Care and Public Health, Imperial College London, United Kingdom (H.T.M.L.).
Marcia C de Oliveira OttoDivision of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston (UTHealth) School of Public Health (M.C.d.O.O.).ORCID 0000-0002-4585-0688
Amanda M FrettsDepartment of Medicine (R.N.L., P.N.J., A.F., N.S., B.M.P.), University of Washington, Seattle.ORCID 0000-0002-5358-2345
Nona SotoodehniaDepartment of Medicine (R.N.L., P.N.J., A.F., N.S., B.M.P.), University of Washington, Seattle.ORCID 0000-0002-2705-6237
Joseph A DiDonatoDepartment of Cardiovascular and Metabolic Sciences (W.H.W.T., Z.W., X.S.L., I.N., J.A.D.D., D.M., S.L.H.), Lerner Research Institute, Cleveland Clinic, OH.ORCID 0000-0002-1641-1758
Fredrik BäckhedWallenberg Laboratory for Cardiovascular and Metabolic Research, University of Gothenburg, Sweden (F.B.).ORCID 0000-0002-4871-8818
Bruce M PsatyDepartment of Medicine (R.N.L., P.N.J., A.F., N.S., B.M.P.), University of Washington, Seattle.ORCID 0000-0002-7278-2190
David S SiscovickThe New York Academy of Medicine, New York (D.S.S.).ORCID 0000-0002-8335-735X
Matthew J BudoffLos Angeles BioMedical Research Institute, Harbor UCLA Medical Center, CA (M.J.B.).ORCID 0000-0002-9616-1946
Dariush Mozaffarian *Department of Cardiovascular and Metabolic Sciences (W.H.W.T., Z.W., X.S.L., I.N., J.A.D.D., D.M., S.L.H.), Lerner Research Institute, Cleveland Clinic, OH.ORCID 0000-0001-7958-9492
Stanley L Hazen *Department of Cardiovascular and Metabolic Sciences (W.H.W.T., Z.W., X.S.L., I.N., J.A.D.D., D.M., S.L.H.), Lerner Research Institute, Cleveland Clinic, OH.ORCID 0000-0001-7124-6639
Funding
Project 3: Microbiota generated aryl sulfates and secondary bile acids in cardiometabolic diseaseP01HL147823 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Joseph DiDonato · 2019 to 2026
$17.0MGut Flora Metabolism of Dietary Phosphatidylcholine and CVDR01HL103866 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2023
$10.8MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MTMAO and Initiation, Extent, and Clinical Onset of Atherosclerotic CVDR01HL135920 · NHLBI · TUFTS UNIVERSITY BOSTON · PI Stanley L Hazen, DARIUSH MOZAFFARIAN · 2017 to 2026
$8.7MCARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
$8.4MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MCHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6MGut microbial dietary phenylalanine metabolism and heart failureR01HL167831 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Stanley L Hazen · 2024 to 2026
$2.4MRole of EIIIA fibronectin in pulmonary fibrosisR01HL085083 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WHITE, ERIC S · 2007 to 2011
$1.9MCORONARY HEART DISEASE &STROKE IN THE ELDERLYN01HC085080 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1988 to 2000
–CORONARY HEART DISEASE AND STROKE IN PEOPLE AGED 65-84N01HC085082 · HC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KULLER, LEWIS H · 1988 to 2000
–CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65 TO 84N01HC085079 · HC · UNIVERSITY OF WASHINGTON · 1988 to 2005
–NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS P01 HL147823NHLBI NIH HHS R01 HL103866NHLBI NIH HHS R01 HL135920NHLBI NIH HHS R01 HL167831NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629
Abstract
backgroundGrowing evidence indicates that trimethylamine
methodsWe evaluated 11 768 participants from the Cardiovascular Health Study and the Multi-Ethnic Study of Atherosclerosis with serial measures of metabolites. Cox proportional hazard models were used to examine the associations between metabolites and incident HF, adjusted for cardiovascular disease risk factors.
resultsIn all, 2102 cases of HF occurred over a median follow-up of 15.9 years. After adjusting for traditional risk factors, higher concentrations of trimethylamine
conclusionsIn this pooled analysis of 2 well-phenotyped, diverse, community-based cohorts, circulating concentrations of gut microbe-derived metabolites such as trimethylamine REGISTRATION: URL: https://www.clinicaltrials.gov/; Unique identifiers: NCT00005133 and NCT00005487.
Indexed as
BetaineCarnitineCholineGastrointestinal MicrobiomeHeart FailureMethylaminesAgedAged, 80 and overBiomarkersFemaleHumansIncidenceMaleMiddle AgedRisk FactorsUnited StatesBetaineBiomarkersCarnitineCholinegamma-butyrobetaineMethylaminestrimethyloxaminecardiovascular diseasescarnitinecholinegastrointestinal microbiomegut microbiotaheart failure
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT00005133ClinicalTrials.gov
NCT00005487ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.