Evidence map›Paper›PMID 39119930›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Magnetically Guided Microcatheter for Targeted Injection of Magnetic Particle Swarms.

Harun Torlakcik, Semih Sevim, Pedro Alves, Michael Mattmann, Joaquim Llacer-Wintle, Maria Pinto, Rosa Moreira, Andreas D Flouris, Fabian C Landers, Xiang-Zhong Chen and 6 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Review
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  8. Review
  9. Magnetically Guided Microcatheter for Targeted Injection of Magnetic Particle Swarms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Harun TorlakcikMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland.
Semih SevimMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland.ORCID 0000-0003-1461-1606
Pedro AlvesTransport Phenomena Research Centre (CEFT), Engineering Faculty, Porto University, Porto, 4200, Portugal.
Michael MattmannMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland.
Joaquim Llacer-WintleMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland.
Maria PintoExperian LDA, Porto, 4200, Portugal.
Rosa MoreiraExperian LDA, Porto, 4200, Portugal.
Andreas D FlourisFAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Karies, 42100, Greece.
Fabian C LandersMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland.
Xiang-Zhong ChenInstitute of Optoelectronics, State Key Laboratory of Photovoltaic Science and Technology, Shanghai Frontiers Science Research Base of Intelligent Optoelectronics and Perception, Fudan University, Shanghai, 200433, P. R. China.
Josep Puigmartí-LuisDepartament de Ciència dels Materials i Química Física, Institut de Química Teòrica i Computacional, University of Barcelona, Martí i Franquès, 1, Barcelona, 08028, Spain.
Quentin BoehlerMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland.
Tiago Sotto MayorTransport Phenomena Research Centre (CEFT), Engineering Faculty, Porto University, Porto, 4200, Portugal.
Minsoo KimMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland.
Bradley J NelsonMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland.
Salvador PanéMulti-Scale Robotics Lab, Institute of Robotics and Intelligent Systems, ETH Zurich, Tannenstrasse 3, Zurich, 8092, Switzerland.ORCID 0000-0003-0147-8287

Funding

Eidgenössische Technische Hochschule Zürich 22-2 ETH-040European Research Council 771565H2020 European Research Council 801464H2020 Future and Emerging Technologies 952152Portugal through FCT/MCTES (PIDDAC) LA/P/0045/2020Portugal through FCT/MCTES (PIDDAC) UIDB/00532/2020Portugal through FCT/MCTES (PIDDAC) UIDP/00532/2020Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 197017Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 198643
6 · The paper itself

Abstract

The initial delivery of small-scale magnetic devices such as microrobots is a key, but often overlooked, aspect for their use in clinical applications. The deployment of these devices within the dynamic environment of the human body presents significant challenges due to their dispersion caused by circulatory flows. Here, a method is introduced to effectively deliver a swarm of magnetic nanoparticles in fluidic flows. This approach integrates a magnetically navigated robotic microcatheter equipped with a reservoir for storing the magnetic nanoparticles. The microfluidic flow within the reservoir facilitates the injection of magnetic nanoparticles into the fluid stream, and a magnetic field gradient guides the swarm through the oscillatory flow to a target site. The microcatheter and reservoir are engineered to enable magnetic steering and injection of the magnetic nanoparticles. To demonstrate this approach, experiments are conducted utilizing a spinal cord phantom simulating intrathecal catheter delivery for applications in the central nervous system. These results demonstrate that the proposed microcatheter successfully concentrates nanoparticles near the desired location through the precise manipulation of magnetic field gradients, offering a promising solution for the controlled deployment of untethered magnetic micro-/nanodevices within the complex physiological circulatory systems of the human body.

Indexed as

CathetersEquipment DesignHumansMagnetic FieldsMagneticsMagnetite NanoparticlesPhantoms, ImagingRoboticsMagnetite Nanoparticlesmagnetic cathetermagnetic controlmagnetic nanoparticlesmagnetic nanoparticle swarmtargeted delivery

Identifiers

PMID39119930
PMCPMC11481240

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.