Evidence map›Paper›PMID 39120293›Full record

ArticleCells2024

The Antidepressant Action of Fluoxetine Involves the Inhibition of

Rym Aouci, Anastasia Fontaine, Amïn Vion, Lou Belz, Giovanni Levi, Nicolas Narboux-Nême

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rym AouciMolecular Physiology and Adaption, UMR7221 CNRS, Museum National d'Histoire Naturelle, 75005 Paris, France.ORCID 0000-0002-6728-0292
Anastasia FontaineMolecular Physiology and Adaption, UMR7221 CNRS, Museum National d'Histoire Naturelle, 75005 Paris, France.
Amïn VionMolecular Physiology and Adaption, UMR7221 CNRS, Museum National d'Histoire Naturelle, 75005 Paris, France.
Lou BelzMolecular Physiology and Adaption, UMR7221 CNRS, Museum National d'Histoire Naturelle, 75005 Paris, France.
Giovanni LeviMolecular Physiology and Adaption, UMR7221 CNRS, Museum National d'Histoire Naturelle, 75005 Paris, France.ORCID 0000-0002-7041-6787
Nicolas Narboux-NêmeMolecular Physiology and Adaption, UMR7221 CNRS, Museum National d'Histoire Naturelle, 75005 Paris, France.ORCID 0000-0002-3791-7459

Funding

Agence National de la Recherche ANR-21-CE14-0072Emergence Sorbonne Université DEDUCEFondation-NRJ-Institut de France N° 216612Museum National d'Histoire Naturelle ATMs Relation & DlxUp
6 · The paper itself

Abstract

Major depressive disorder (MDD) is a complex and devastating illness that affects people of all ages. Despite the large use of antidepressants in current medical practice, neither their mechanisms of action nor the aetiology of MDD are completely understood. Experimental evidence supports the involvement of Parvalbumin-positive GABAergic neurons (PV-neurons) in the pathogenesis of MDD.

Indexed as

Antidepressive AgentsCerebral CortexFluoxetineGABAergic NeuronsHomeodomain ProteinsReceptor, trkBAnimalsMajor Depressive DisorderMaleMiceMice, Inbred C57BLSignal TransductionAntidepressive AgentsDlx5 protein, mouseDlx6 protein, mouseFluoxetineHomeodomain ProteinsNtrk2 protein, mouseReceptor, trkBdepressionDlx5/6fluoxetineParvalbumineTrkB-CREB

Identifiers

PMID39120293
PMCPMC11311550

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.