ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2024
Sodium butyrate prevents cytokine-induced β-cell dysfunction through restoration of stromal interaction molecule 1 expression and activation of store-operated calcium entry.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Chih-Chun LeeCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-2802-519X
Tatsuyoshi KonoCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-7524-6836
Farooq SyedCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-0284-0631
Staci A WeaverCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-2974-2580
Paul SohnCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0001-7126-8459
Wenting WuCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0003-0982-771X
Garrick ChangDepartment of Physics, Indiana University Indianapolis, Indianpolis, Indiana, USA.ORCID 0009-0007-0741-7588
Jing LiuDepartment of Physics and Astronomy, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0002-4912-4560
Marjan Slak RupnikCenter for Physiology and Pharmacology, Medical University of Vienna, Wien, Austria.ORCID 0000-0002-3744-4882
Carmella Evans-MolinaCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0001-7764-8663
Funding
NIDDK Network Coordinating UnitU24DK097771 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Shuibing Chen, Jeffrey S. Grethe · 2013 to 2026
$20.9M
Integrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8M
Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
The Integrated Stress Response in Human Islets During Early T1DU01DK127786 · NIDDK · UNIVERSITY OF CHICAGO · PI EVANS-MOLINA, CARMELLA, MIRMIRA, RAGHAVENDRA G · 2020 to 2025
$7.1M
Mechanisms of Beta Cell Function in Health and DiseaseR01DK093954 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EVANS-MOLINA, CARMELLA · 2011 to 2019
$3.5M
Biomarkers Of Beta Cell Stress In Type 1 Diabetes (BetaMarker)UC4DK104166 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EIZIRIK, DECIO LAKS, EVANS-MOLINA, CARMELLA · 2014 to 2014
$2.4M
Control of beta cell function and survival by RYR2-mediated calcium signalsR01DK127236 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EVANS-MOLINA, CARMELLA · 2021 to 2025
$2.2M
β cell miRNAs Function as Molecular Hubs of Type 1 Diabetes PathogenesisR01DK127308 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EVANS-MOLINA, CARMELLA · 2021 to 2024
$1.7M
Regulation of Calcium Homeostasis in the Pancreatic Beta CellI01BX001733 · VA · RLR VA MEDICAL CENTER · PI Carmella Evans-Molina · 2013 to 2026
–
Ball Brothers Foundation (BBF)BLRD VA I01 BX001733George and Frances Ball Foundation (GFBF)HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P30-DK-097512HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK093954HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK127236HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK127308HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) U01DK127786HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) U24DK097771HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) UC4DK104166NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK093954NIDDK NIH HHS R01 DK127236NIDDK NIH HHS R01 DK127308NIDDK NIH HHS U01 DK127786NIDDK NIH HHS U24 DK097771NIDDK NIH HHS U24 DK098085NIDDK NIH HHS UC4 DK104166Sigma Beta SororityVA | U.S. Department of Veterans Affairs I01BX001733
6 · The paper itself
Abstract
Sodium butyrate (NaB) improves β-cell function in preclinical models of diabetes; however, the mechanisms underlying these beneficial effects have not been fully elucidated. In this study, we investigated the impact of NaB on β-cell function and calcium (Ca
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Sodium butyrate prevents cytokine-induced β-cell dysfunction through restoration of stromal interaction molecule 1 expression and activation of store-operated calcium entry. · full record | Socratic