Evidence map›Paper›PMID 39120784›Full record

ArticleCellular and molecular life sciences : CMLS2024

Key role of the TM2-TM3 loop in calcium potentiation of the α9α10 nicotinic acetylcholine receptor.

Sofia L Gallino, Lucía Agüero, Juan C Boffi, Gustavo Schottlender, Paula Buonfiglio, Viviana Dalamon, Irina Marcovich, Agustín Carpaneto, Patricio O Craig, Paola V Plazas and 1 more

Abstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sofia L GallinoInstituto de Investigaciones en Ingeniería Genética y Biología Molecular ''Dr. Héctor N. Torres'' (INGEBI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.ORCID https://orcid.org/0000-0002-3529-653X
Lucía AgüeroInstituto de Investigaciones en Ingeniería Genética y Biología Molecular ''Dr. Héctor N. Torres'' (INGEBI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.ORCID https://orcid.org/0009-0008-6253-3837
Juan C BoffiInstituto de Investigaciones en Ingeniería Genética y Biología Molecular ''Dr. Héctor N. Torres'' (INGEBI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.ORCID https://orcid.org/0000-0002-0116-6892
Gustavo SchottlenderInstituto de Cálculo, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Paula BuonfiglioInstituto de Investigaciones en Ingeniería Genética y Biología Molecular ''Dr. Héctor N. Torres'' (INGEBI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.ORCID https://orcid.org/0000-0003-2985-4790
Viviana DalamonInstituto de Investigaciones en Ingeniería Genética y Biología Molecular ''Dr. Héctor N. Torres'' (INGEBI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.ORCID https://orcid.org/0000-0001-5283-4726
Irina MarcovichInstituto de Investigaciones en Ingeniería Genética y Biología Molecular ''Dr. Héctor N. Torres'' (INGEBI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.ORCID https://orcid.org/0000-0002-2521-7340
Agustín CarpanetoInstituto de Investigaciones en Ingeniería Genética y Biología Molecular ''Dr. Héctor N. Torres'' (INGEBI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.ORCID https://orcid.org/0000-0002-2880-1710
Patricio O CraigDepartamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina. pocraig@gmail.com.ORCID https://orcid.org/0000-0002-9052-2018
Paola V Plazas *Instituto de Farmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina. pvplazas@gmail.com.ORCID http://orcid.org/0000-0001-8195-484X
Ana B Elgoyhen *Instituto de Investigaciones en Ingeniería Genética y Biología Molecular ''Dr. Héctor N. Torres'' (INGEBI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. abelgoyhen@gmail.com.ORCID https://orcid.org/0000-0001-9487-0311

Funding

Fondo para la Investigación Científica y Tecnológica PICT 2021-00818
6 · The paper itself

Abstract

The α9α10 nicotinic cholinergic receptor (nAChR) is a ligand-gated pentameric cation-permeable ion channel that mediates synaptic transmission between descending efferent neurons and mechanosensory inner ear hair cells. When expressed in heterologous systems, α9 and α10 subunits can assemble into functional homomeric α9 and heteromeric α9α10 receptors. One of the differential properties between these nAChRs is the modulation of their ACh-evoked responses by extracellular calcium (Ca

Indexed as

CalciumReceptors, NicotinicAcetylcholineAmino Acid SequenceAnimalsBinding SitesMolecular Dynamics SimulationPatch-Clamp TechniquesProtein SubunitsRatsXenopus laevisAcetylcholineCalciumChrna10 protein, ratChrna9 protein, ratProtein SubunitsReceptors, NicotinicCalcium modulationLigand-gated ion channelsNicotinic acetylcholine receptorα9α10 receptors

Identifiers

PMID39120784
PMCPMC11335262

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.