Evidence map›Paper›PMID 39124617›Full record

ReviewJournal of clinical medicine2024

A Look at Primary and Secondary Prevention in the Elderly: The Two Sides of the Same Coin.

Maurizio Giuseppe Abrignani, Fabiana Lucà, Vincenzo Abrignani, Giuseppe Pelaggi, Alessandro Aiello, Furio Colivicchi, Francesco Fattirolli, Michele Massimo Gulizia, Federico Nardi, Paolo Giuseppe Pino and 2 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. ANMCO position paper E-health integration in cardiology clinical care framework.European heart journal supplements : journal of the European Society of Cardiology · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maurizio Giuseppe AbrignaniO.U. Cardiology-ICCU, P. Borsellino Hospital, ASP Trapani, 91025 Marsala, Italy.
Fabiana LucàO.U. Interventional Cardiology, Bianchi Melacrino Morelli Hospital, 89124 Reggio Calabria, Italy.ORCID 0000-0002-5369-5382
Vincenzo AbrignaniInternal Medicine and Stroke Care Ward, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90141 Palermo, Italy.
Giuseppe PelaggiO.U. Interventional Cardiology, Bianchi Melacrino Morelli Hospital, 89124 Reggio Calabria, Italy.
Alessandro AielloCardiology Division, San Filippo Neri Hospital, 00135 Rome, Italy.
Furio ColivicchiCardiology Division, San Filippo Neri Hospital, 00135 Rome, Italy.
Francesco FattirolliDepartment of Experimental and Clinical Medicine, Careggi University Hospital, University of Florence, 50121 Firenze, Italy.
Michele Massimo GuliziaO.U. Cardiology, Garibaldi-Nesima Hospital, ARNAS Garibaldi, 95123 Catania, Italy.
Federico NardiO.U. Cardiology, Santo Spirito Hospital, 15033 Casale Monferrato, Italy.
Paolo Giuseppe PinoHeart Diagnostics Division, A.O. S. Camillo-Forlanini, 00152 Rome, Italy.
Iris ParriniCardiology Department, Mauriziano Umberto I Hospital, 10128 Turin, Italy.ORCID 0000-0002-0038-9445
Carmelo Massimiliano RaoO.U. Interventional Cardiology, Bianchi Melacrino Morelli Hospital, 89124 Reggio Calabria, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global population is experiencing an aging trend; however, this increased longevity is not necessarily accompanied by improved health in older age. A significant consequence of this demographic shift is the rising prevalence of multiple chronic illnesses, posing challenges to healthcare systems worldwide. Aging is a major risk factor for multimorbidity, which marks a progressive decline in resilience and a dysregulation of multisystem homeostasis. Cardiovascular risk factors, along with aging and comorbidities, play a critical role in the development of heart disease. Among comorbidities, age itself stands out as one of the most significant risk factors for cardiovascular disease, with its prevalence and incidence notably increasing in the elderly population. However, elderly individuals, especially those who are frail and have multiple comorbidities, are under-represented in primary and secondary prevention trials aimed at addressing traditional cardiovascular risk factors, such as hypercholesterolemia, diabetes mellitus, and hypertension. There are concerns regarding the optimal intensity of treatment, taking into account tolerability and the risk of drug interactions. Additionally, uncertainty persists regarding therapeutic targets across different age groups. This article provides an overview of the relationship between aging and cardiovascular disease, highlighting various cardiovascular prevention issues in the elderly population.

Indexed as

agingcardiovascular preventioncomorbidityelderlyrisk factors

Identifiers

PMID39124617
PMCPMC11312802

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.