Evidence map›Paper›PMID 39125052›Full record

ArticleMolecules (Basel, Switzerland)2024

Cheminformatics-Guided Exploration of Synthetic Marine Natural Product-Inspired Brominated Indole-3-Glyoxylamides and Their Potentials for Drug Discovery.

Darren C Holland, Dale W Prebble, Mark J Calcott, Wayne A Schroder, Francesca Ferretti, Aaron Lock, Vicky M Avery, Milton J Kiefel, Anthony R Carroll

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Darren C HollandSchool of Environment and Science, Griffith University, Southport, QLD 4222, Australia.ORCID 0000-0002-2498-6084
Dale W PrebbleSchool of Environment and Science, Griffith University, Southport, QLD 4222, Australia.ORCID 0000-0002-7084-8299
Mark J CalcottSchool of Biological Sciences, Victoria University of Wellington, Wellington 6102, New Zealand.ORCID 0000-0002-7736-8095
Wayne A SchroderSchool of Environment and Science, Griffith University, Nathan, QLD 4111, Australia.
Francesca FerrettiSchool of Environment and Science, Griffith University, Southport, QLD 4222, Australia.
Aaron LockSchool of Environment and Science, Griffith University, Nathan, QLD 4111, Australia.
Vicky M AverySchool of Environment and Science, Griffith University, Nathan, QLD 4111, Australia.ORCID 0000-0003-4914-2299
Milton J KiefelSchool of Environment and Science, Griffith University, Southport, QLD 4222, Australia.
Anthony R CarrollSchool of Environment and Science, Griffith University, Southport, QLD 4222, Australia.ORCID 0000-0001-7695-8301

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Marine natural products (MNPs) continue to be tested primarily in cellular toxicity assays, both mammalian and microbial, despite most being inactive at concentrations relevant to drug discovery. These MNPs become missed opportunities and represent a wasteful use of precious bioresources. The use of cheminformatics aligned with published bioactivity data can provide insights to direct the choice of bioassays for the evaluation of new MNPs. Cheminformatics analysis of MNPs found in MarinLit (

Indexed as

Biological ProductsCheminformaticsDrug DiscoveryAnimalsAquatic OrganismsHumansIndole AlkaloidsIndolesPlasmodium falciparumSARS-CoV-2Biological ProductsIndole AlkaloidsIndolescheminformaticsindol-3-yl-glyoxylamidesindole synthesismalariamarine indole alkaloidsmarine natural productsParkinson’s diseaseproteaseSARS-CoV-2

Identifiers

PMID39125052
PMCPMC11314621

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.