Evidence map›Paper›PMID 39125404›Full record

ReviewNutrients2024

The Impact of the Mediterranean Diet on Telomere Biology: Implications for Disease Management-A Narrative Review.

Stella Baliou, Petros Ioannou, Miruna-Maria Apetroaei, Elena Vakonaki, Persefoni Fragkiadaki, Evangelos Kirithras, Manolis N Tzatzarakis, Andreea Letitia Arsene, Anca Oana Docea, Aristides Tsatsakis

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stella BaliouLaboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece.
Petros IoannouSchool of Medicine, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0003-1082-5674
Miruna-Maria ApetroaeiFaculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6, Traian Vuia Street, 020956 Bucharest, Romania.
Elena VakonakiLaboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece.
Persefoni FragkiadakiLaboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece.
Evangelos KirithrasLaboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece.
Manolis N TzatzarakisLaboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece.
Andreea Letitia ArseneFaculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6, Traian Vuia Street, 020956 Bucharest, Romania.ORCID 0000-0002-9478-6176
Anca Oana DoceaDepartment of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.ORCID 0000-0002-8162-5955
Aristides TsatsakisLaboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece.ORCID 0000-0003-3824-2462

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTelomeres are nucleoprotein complexes at the ends of chromosomes that are under the control of genetic and environmental triggers. Accelerated telomere shortening is causally implicated in the increasing incidence of diseases. The Mediterranean diet has recently been identified as one that confers protection against diseases. This review aimed to identify the effect of each component of the Mediterranean diet on telomere length dynamics, highlighting the underlying molecular mechanisms.

methodsPubMed was searched to identify relevant studies to extract data for conducting a narrative review.

resultsThe Mediterranean diet alleviates clinical manifestations in many diseases. Focusing on autoimmune diseases, the Mediterranean diet can be protective by preventing inflammation, mitochondrial malfunction, and abnormal telomerase activity. Also, each Mediterranean diet constituent seems to attenuate aging through the sustenance or elongation of telomere length, providing insights into the underlying molecular mechanisms. Polyphenols, vitamins, minerals, and fatty acids seem to be essential in telomere homeostasis, since they inhibit inflammatory responses, DNA damage, oxidative stress, mitochondrial malfunction, and cell death and induce telomerase activation.

conclusionsThe Mediterranean diet is beneficial for maintaining telomere dynamics and alleviating age-related illnesses. This review provides a comprehensive overview of cross-sectional, observational, and randomized controlled trials regarding the beneficial impact of every constituent in the Mediterranean diet on telomere length and chronic disease management.

Indexed as

Diet, MediterraneanTelomereAgingAutoimmune DiseasesDisease ManagementHumansOxidative StressPolyphenolsTelomeraseTelomere HomeostasisTelomere ShorteningPolyphenolsTelomeraseanti-inflammatoryantioxidantautoimmunitydiseasesfatty acidsMediterranean dietmineralspolyphenolstelomere lengthvitamins

Identifiers

PMID39125404
PMCPMC11313773

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.