Evidence map›Paper›PMID 39125451›Full record

Trial reportNutrients2024

The Effect of 4-Month Treatment with Glycocalyx Dietary Supplement on Endothelial Glycocalyx Integrity and Vascular Function in Patients with Psoriasis.

Ignatios Ikonomidis, Eleni Katsanaki, John Thymis, George Pavlidis, Kyriaki Lampadaki, Konstantinos Katogiannis, Aristeidis Vaiopoulos, Vicky Lazarou, Gavriella Kostelli, Eleni Michalopoulou and 7 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ignatios Ikonomidis2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece.ORCID 0000-0001-8241-7886
Eleni Katsanaki2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece.ORCID 0009-0009-1025-9917
John Thymis2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece.ORCID 0000-0002-3916-5350
George Pavlidis2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece.ORCID 0000-0003-3220-3446
Kyriaki Lampadaki2nd Department of Dermatology and Venereology, Attikon University Hospital, Medical School, National & Kapodistrian University of Athens, 12461 Athens, Greece.
Konstantinos Katogiannis2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece.ORCID 0000-0003-1631-5210
Aristeidis Vaiopoulos2nd Department of Dermatology and Venereology, Attikon University Hospital, Medical School, National & Kapodistrian University of Athens, 12461 Athens, Greece.ORCID 0000-0002-8838-5309
Vicky Lazarou2nd Department of Dermatology and Venereology, Attikon University Hospital, Medical School, National & Kapodistrian University of Athens, 12461 Athens, Greece.
Gavriella Kostelli2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece.ORCID 0000-0002-1732-2255
Eleni Michalopoulou2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece.
Sotirios PililisResearch Unit and Diabetes Center, 2nd Department of Internal Medicine, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece.ORCID 0009-0005-6480-3878
Dimitrios Vlachomitros2nd Cardiology Department, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece.
Konstantinos Theodoropoulos2nd Department of Dermatology and Venereology, Attikon University Hospital, Medical School, National & Kapodistrian University of Athens, 12461 Athens, Greece.ORCID 0000-0001-6272-4459
Hans VinkGlycoCalyx Research Institute, Alpine, UT 84004, USA.
Robert LongGlycoCalyx Research Institute, Alpine, UT 84004, USA.
Evangelia Papadavid2nd Department of Dermatology and Venereology, Attikon University Hospital, Medical School, National & Kapodistrian University of Athens, 12461 Athens, Greece.
Vaia LambadiariResearch Unit and Diabetes Center, 2nd Department of Internal Medicine, Attikon University Hospital, National & Kapodistrian University of Athens, 12461 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis predisposes to cardiovascular dysfunction. We investigated whether glycocalyx dietary supplement (GDS), which contains glycosaminoglycans and fucoidan, improves endothelial glycocalyx and arterial stiffness in psoriatic patients. Fifty participants with psoriasis under biological agents were randomly assigned to GDS (n = 25) or placebo (n = 25) for 4 months. We measured at baseline and at follow-up: (a) perfused boundary region (PBR) of the sublingual microvessels (range 4 to 25 μm), a marker of endothelium glycocalyx integrity; (b) carotid-femoral pulse wave velocity (PWV-Complior SP-ALAM) and augmentation index (AIx), markers of arterial stiffness and (c) psoriasis area and severity index (PASI) score. Both groups displayed a similar decrease in PASI at four months (

Indexed as

Dietary SupplementsEndothelium, VascularGlycocalyxPsoriasisVascular StiffnessAdultDouble-Blind MethodFemaleHumansMaleMiddle AgedTreatment Outcomearterial stiffnessaugmentation indexfucoidanglycocalyxglycocalyx dietary supplementpsoriasispulse wave velocity

Identifiers

PMID39125451
PMCPMC11313920

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.