Evidence map›Paper›PMID 39126568›Full record

ArticleInflammopharmacology2024

Gastroprotective role of a flavonoid-rich subfraction from Fridericia chica (Bonpl.) L. G. Lohmann: a medicinal plant used in the Amazon region.

Daniela Miorando, Amanda M Steffler, Cristian A Dalla Vecchia, Viviane L Simomura, Jaqueline J Veloso, Maike V Buzatto, Ruan K S Nunes, Lincon B Somensi, Max V Gutiérrez, Lorane I S H Melim and 6 more

Abstract read
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In one paragraph

Article in Inflammopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daniela MiorandoPostgraduate Program in Health Sciences, Community University of Chapecó Region, Chapecó, SC, Brazil.
Amanda M StefflerPostgraduate Program in Health Sciences, Community University of Chapecó Region, Chapecó, SC, Brazil.
Cristian A Dalla VecchiaPostgraduate Program in Health Sciences, Community University of Chapecó Region, Chapecó, SC, Brazil.
Viviane L SimomuraPostgraduate Program in Health Sciences, Community University of Chapecó Region, Chapecó, SC, Brazil.
Jaqueline J VelosoLaboratory of Pharmacognosy, Community University of the Chapecó Region, Chapecó, SC, Brazil.
Maike V BuzattoLaboratory of Pharmacognosy, Community University of the Chapecó Region, Chapecó, SC, Brazil.
Ruan K S NunesPostgraduate Program in Pharmaceutical Sciences, University of Vale Do Itajaí, Itajaí, SC, Brazil.
Lincon B SomensiPostgraduate Program in Development and Society, University of Alto Vale Do Rio Do Peixe, Caçador, SC, Brazil.
Max V GutiérrezDepartment of Chemical, Biological and Agricultural Sciences, Universidad de Sonora, Navojoa Sonora, Mexico.
Lorane I S H MelimPharmacy Course, Federal University of Amapá, Macapá, AP, Brazil.
Franco M M PontesPharmacy Course, Federal University of Amapá, Macapá, AP, Brazil.
Luisa M SilvaLaboratory of TGI Pharmacology and Interactions, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Anzhela VeselinovaDepartment of Physical Chemistry, Faculty of Chemical Sciences, University of Salamanca, Salamanca, Spain.
Lola González-SánchezDepartment of Physical Chemistry, Faculty of Chemical Sciences, University of Salamanca, Salamanca, Spain.
Pablo G JambrinaDepartment of Physical Chemistry, Faculty of Chemical Sciences, University of Salamanca, Salamanca, Spain.
Walter A Roman JuniorPostgraduate Program in Health Sciences, Community University of Chapecó Region, Chapecó, SC, Brazil. romanwa@unochapeco.edu.br.ORCID http://orcid.org/0000-0001-8363-8795

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fridericia chica is an Amazonian plant used to treat stomach disorders. However, the pharmacological activity of flavonoids in the extract has yet to be investigated. Therefore, we considered that a flavonoid-rich F. chica subfraction (FRS) has gastroprotective functions. For this, before the induction of gastric ulcers with ethanol or piroxicam, the rats received vehicle (water), omeprazole (30 mg/kg), or FRS (30 mg/kg), and the ulcer area was measured macro and microscopically, and the antisecretory action was investigated in pylorus-ligated rats. In addition, the roles of nitric oxide (NO) and nonprotein sulfhydryl compounds (NP-SH) in the gastroprotective effects of FRS were studied. FRS reduced ethanol- and piroxicam-induced ulcerations by 81% and 77%, respectively, as confirmed histologically. Antioxidant effects were observed for FRS through the maintenance of GSH and LPO levels, and the SOD and CAT activity similar to those found in the nonulcerated group. Moreover, FRS avoided the increase in MPO activity and TNF, IL-6, IL-4 and IL-10 levels. Moreover, mucin staining increased in ulcerated rats receiving FRS, and the pharmacological mechanism gastroprotective seems to involve the NO and NP-SH in addition to antisecretory actions. The chemical study by mass spectrometry confirmed the presence of flavonoids in FRS, and molecular docking studies have shown that these compounds interact with cyclooxygenase-1 and NO synthase. Furthermore, there was no indication that FRS had cytotoxic effects. Our results support the popular use of F. chica, and we conclude that the gastroprotection effect promoted by FRS can be attributed to the combined effect of the flavonoids.

Indexed as

AntioxidantsAnti-Ulcer AgentsFlavonoidsPlant ExtractsPlants, MedicinalRats, WistarStomach UlcerAnimalsFabaceaeGastric MucosaMaleMolecular Docking SimulationNitric OxideRatsAntioxidantsAnti-Ulcer AgentsFlavonoidsNitric OxidePlant ExtractsMedicinal plant; anti-ulcer; molecular docking; Amazon plant

Identifiers

PMID39126568

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.