Evidence map›Paper›PMID 39128689›Full record

ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2024

Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice.

Laura E Ewing, Ryan J Harpenau, Charles M Skinner, Kirsten Clement, Charles M Quick, Eric U Yee, D Keith Williams, Larry A Walker, Mahmoud A ElSohly, Bill J Gurley and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura E EwingDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Ryan J HarpenauDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Charles M SkinnerDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA; Arkansas Children's Research Institute, Little Rock, AR, USA.
Kirsten ClementDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Charles M QuickDepartment of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Eric U YeeDepartment of Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
D Keith WilliamsDepartment of Biostatistics, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Larry A WalkerNational Center for Natural Products Research, University of Mississippi University, MS, 38677, USA.
Mahmoud A ElSohlyNational Center for Natural Products Research, University of Mississippi University, MS, 38677, USA; ElSohly Laboratories, Inc. (ELI), Oxford, MS, 38677, USA.
Bill J GurleyCenter for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA; National Center for Natural Products Research, University of Mississippi University, MS, 38677, USA.
Igor KoturbashDepartment of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. Electronic address: ikoturbash@uams.edu.

Funding

The Role of the Mitochondrion in the Metabolic Stress Response to Burn TraumaP20GM109096 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI BORSHEIM, ELISABET · 2016 to 2025
$20.7M
Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
Arkansas Center for Clinical Translational ResearchKL2TR000063 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$459k
NCATS NIH HHS KL2 TR000063NCATS NIH HHS UL1 TR000039NIGMS NIH HHS P20 GM109096
6 · The paper itself

Abstract

Cannabidiol (CBD) has gained widespread popularity; however, its pharmacological and toxicological profiles in the context of human genetic diversity remain largely unexplored. Here, we investigated the variability in metabolism and toxicity of CBD-rich cannabis extract (CRCE) in genetically diverse mouse models: C57BL/6J, B6C3F

Indexed as

CannabidiolCannabisMice, Inbred C57BLPlant ExtractsAnimalsBilirubinLiverMaleMiceSpecies SpecificityBilirubinCannabidiolPlant ExtractsCannabidiol-rich cannabis extractCytochromesGenetic diversityHepatotoxicityMetabolismMouse model

Identifiers

PMID39128689
PMCPMC11381146

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.