Impact of epicardial fat on coronary vascular function, cardiac morphology, and cardiac function in women with suspected INOCA.
Sauyeh K Zamani, Janet Wei, Brandon Hathorn, Erica Robuck, Alan C Kwan, Carl J Pepine, Eileen Handberg, Daisha J Cipher, Damini Dey, C Noel Bairey Merz and 1 more
Article in European heart journal. Cardiovascular Imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
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2 · The registry
The trial behind it
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5 · Who and what money
Authors and funding
11 authors.
Sauyeh K ZamaniCollege of Nursing and Health Innovation, University of Texas at Arlington, 701 S. Nedderman Drive Dr., Arlington, TX 76019, USA.ORCID 0000-0003-1484-5226
Janet WeiBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.ORCID 0000-0002-1311-618X
Brandon HathornCollege of Nursing and Health Innovation, University of Texas at Arlington, 701 S. Nedderman Drive Dr., Arlington, TX 76019, USA.
Erica RobuckCollege of Nursing and Health Innovation, University of Texas at Arlington, 701 S. Nedderman Drive Dr., Arlington, TX 76019, USA.
Alan C KwanDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Carl J PepineDivision of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA.
Eileen HandbergDivision of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA.
Daisha J CipherCollege of Nursing and Health Innovation, University of Texas at Arlington, 701 S. Nedderman Drive Dr., Arlington, TX 76019, USA.
Damini DeyBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.ORCID 0000-0003-2236-6970
C Noel Bairey MerzBarbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA.
Michael D NelsonCollege of Nursing and Health Innovation, University of Texas at Arlington, 701 S. Nedderman Drive Dr., Arlington, TX 76019, USA.ORCID 0000-0002-3232-8639
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
The Microvascular Aging and Eicosanoids - Women's Evaluation of Systemic Aging Tenacity (MAE-WEST) ("You are never too old to become younger!") Specialized Center for Research Excellence (SCORE)U54AG065141 · NIA · CEDARS-SINAI MEDICAL CENTER · PI SHYY, JOHN YJ · 2020 to 2024
$8.7M
Women's Ischemia Syndrome EvaluationU01HL064829 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KELSEY, SHERYL F. · 2001 to 2005
$3.9M
Women's Ischemia Syndrome Evaluation (WISE) - Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure with Preserved Ejection Fraction (HFpEF)R01HL146158 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL · 2019 to 2023
$3.7M
Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular DysfunctionR01HL090957 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI BAIREY MERZ, CATHLEEN NOEL, PEPINE, CARL J · 2008 to 2013
$3.5M
Whole-Heart Myocardial Blood Flow Quantification Using MRIR01HL124649 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO · 2015 to 2018
$3.3M
Myocardial Steatosis in Women with Coronary Microvascular Dysfunction: Defining the Pathway to Heart Failure with Preserved Ejection Fraction (HFpEF)R01HL153500 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI WEI, JANET · 2021 to 2025
$3.2M
Behavioral Medicine and Cardiovascular Research TrainingT32HL069751 · NHLBI · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI KRANTZ, DAVID S. · 2003 to 2007
$1.2M
Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young WomenK23HL127262 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SHUFELT, CHRISANDRA LEE · 2016 to 2020
$988k
Magnetic Resonance Imaging for Global Atherosclerosis Risk AssessmentK23HL125941 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI WEI, JANET · 2016 to 2020
$985k
ISCHEMIC HEART DISEASE IN WOMEN--CLINICAL CENTERN01HV068163 · HV · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 1996 to 2001
$386k
American Heart Association-American Stroke Association 23CDA1053659Barbra Streisand Women's Cardiovascular Research and Education ProgramCedars-Sinai Medical CenterConstance Austin Women's Heart Research FellowshipsErika Glazer Women's Heart Health Project, and the Adelson Family FoundationGustavus and Louis Pfeiffer Research FoundationLadies Hospital Aid Society of Western PennsylvaniaLinda Joy Pollin Women's Heart Health ProgramNational Heart, Lung, and Blood Institutes N01-HV-068161, N01-HV-068162, N01-HV-068163, N01-HV-068164NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCATS NIH HHS UL1 TR001881NCRR NIH HHSNHLBI NIH HHS K23 HL125941NHLBI NIH HHS K23 HL127262NHLBI NIH HHS N01 HV068161NHLBI NIH HHS N01 HV068162NHLBI NIH HHS N01 HV068163NHLBI NIH HHS N01 HV068164NHLBI NIH HHS R01 HL090957NHLBI NIH HHS R01 HL124649NHLBI NIH HHS R01 HL146158NHLBI NIH HHS R01 HL153500NHLBI NIH HHS R21 HL167171NHLBI NIH HHS T32 HL069751NHLBI NIH HHS U01 HL064829NIA NIH HHS R03 AG032631NIA NIH HHS U54 AG065141Society for Women's Health ResearchWomen's Guild of Cedars-Sinai Medical Center
6 · The paper itself
Abstract
aimsEpicardial fat is a metabolically active adipose tissue depot situated between the myocardium and visceral pericardium that covers ∼80% of the heart surface. While epicardial fat has been associated with the development of atherosclerotic coronary artery disease, less is known about the relationship between epicardial fat and coronary vascular function. Moreover, the relations between excess epicardial fat and cardiac morphology and function remain incompletely understood. METHODS AND
resultsTo address these knowledge gaps, we retrospectively analysed data from 294 individuals from our database of women with suspected ischaemia with no obstructive coronary disease (INOCA) who underwent both invasive coronary function testing and cardiac magnetic resonance imaging. Epicardial fat area, biventricular morphology, and function, as well as left atrial function, were assessed from cine images, per established protocols. The major novel findings were two-fold: first, epicardial fat area was not associated with coronary vascular dysfunction. Secondly, epicardial fat was associated with increased left ventricular concentricity (β = 0.15, P = 0.01), increased septal thickness (β = 0.17, P = 0.002), and reduced left atrial conduit fraction (β = -0.15, P = 0.02), even after accounting for age, BMI, and history of hypertension.
conclusionTaken together, these data do not support a measurable relationship between epicardial fat and coronary vascular dysfunction but do suggest that epicardial fat may be related to concentric remodelling and diastolic dysfunction in women with suspected INOCA. Prospective studies are needed to elucidate the long-term impact of epicardial fat in this patient population.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Impact of epicardial fat on coronary vascular function, cardiac morphology, and cardiac function in women with suspected INOCA. · full record | Socratic