ArticleActas espanolas de psiquiatria2024
Causality between Sarcopenia and Depression: A Bidirectional Mendelian Randomization Study.
Article in Actas espanolas de psiquiatria, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Sarcopenia and depression: a strong association in older adults with type 2 diabetes in Vietnam.BMC geriatrics · 2026Article
- The association between nutritional status, sarcopenia, and depressive symptoms in elderly Chinese patients receiving maintenance hemodialysis: a hospital-based cross-sectional study.Frontiers in nutrition · 2026Article
- Association between subjective well-being and low muscle mass among Chinese older adults: a nationwide cross-sectional study.BMC geriatrics · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
backgroundNumerous observational studies have suggested a correlation between sarcopenia and depression, but the nature of this relationship requires further investigation.
methodsThis study employed bidirectional Mendelian randomization to explore this connection. Data from genome-wide association studies were used, encompassing measures of sarcopenia and mental factors, including depression and emotional states. The initial analysis concentrated on the impact of depression on sarcopenia, and then it examined the reverse relationship. The same methodology was applied to emotional data for validation.
resultsThe results indicated a reciprocal causation between sarcopenia and depression, even when emotional state data were considered. Various emotions can impact sarcopenia, and in turn, sarcopenia can affect emotions, except subjective well-being. These findings highlight a cyclic deterioration between sarcopenia and depression, with a link to negative emotions and a partially ameliorative effect of subjective well-being on sarcopenia.
conclusionsIn summary, this study sheds light on the interplay between psychiatric factors and sarcopenia, offering insights into intervention and prevention strategies.
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