Evidence map›Paper›PMID 39131322›Full record

ArticlebioRxiv : the preprint server for biology2024

Effects of ketamine on GABAergic and glutamatergic activity in the mPFC: biphasic recruitment of GABA function in antidepressant-like responses.

Manoela V Fogaça, Fernanda Daher, Marina R Picciotto

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Manoela V FogaçaDepartment of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.ORCID 0000-0003-4212-7424
Fernanda DaherDepartment of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA.
Marina R PicciottoDepartment of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA.ORCID 0000-0002-4404-1280

Funding

Cholinergic Contribution to Circuits Underlying DepressionR01MH077681 · NIMH · YALE UNIVERSITY · PI MINEUR, YANN SEBASTIEN, PICCIOTTO, MARINA R · 2006 to 2025
$7.0M
Synaptic mechanisms underlying the rapid antidepressant actions of scopolamineR01MH105910 · NIMH · YALE UNIVERSITY · PI PICCIOTTO, MARINA R · 2014 to 2018
$2.2M
Cortical GABAergic mechanisms underlying rapid and sustained antidepressant responsesR00MH126098 · NIMH · UNIVERSITY OF ROCHESTER · PI FOGACA, MANOELA · 2023 to 2025
$730k
Cortical GABAergic mechanisms underlying rapid and sustained antidepressant responsesK99MH126098 · NIMH · YALE UNIVERSITY · PI FOGACA, MANOELA · 2022 to 2022
$102k
NIMH NIH HHS K99 MH126098NIMH NIH HHS R00 MH126098NIMH NIH HHS R01 MH077681NIMH NIH HHS R01 MH105910
6 · The paper itself

Abstract

Major depressive disorder (MDD) is associated with disruptions in glutamatergic and GABAergic activity in the medial prefrontal cortex (mPFC), leading to altered synaptic formation and function. Low doses of ketamine rapidly rescue these deficits, inducing fast and sustained antidepressant effects. While it is suggested that ketamine produces a rapid glutamatergic enhancement in the mPFC, the temporal dynamics and the involvement of GABA interneurons in its sustained effects remain unclear. Using simultaneous photometry recordings of calcium activity in mPFC pyramidal and GABA neurons, as well as chemogenetic approaches in

Indexed as

antidepressantsdepressionGABAglutamateketaminemPFCplasticitystress

Identifiers

PMID39131322
PMCPMC11312475

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.