Evidence map›Paper›PMID 39132849›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Spatial and temporal patterns of cortical mean diffusivity in Alzheimer's disease and suspected non-Alzheimer's disease pathophysiology.

Pan Sun, Zhengbo He, Anqi Li, Jie Yang, Yalin Zhu, Yue Cai, Ting Ma, Shaohua Ma, Tengfei Guo, Alzheimer's Disease Neuroimaging Initiative

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  8. Association of plasma p-tau and p-tau/Aβ ratio with Alzheimer's pathology.The journal of prevention of Alzheimer's disease · 2026
    Article
  9. Article
  10. Article
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  14. Detecting Alzheimer's disease using digital virtual reality cognitive tests.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pan SunInstitute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.
Zhengbo HeInstitute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.
Anqi LiInstitute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.
Jie YangInstitute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.
Yalin ZhuInstitute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.
Yue CaiInstitute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.
Ting MaSchool of Electronic and Information Engineering, Harbin Institute of Technology (Shenzhen), Shenzhen, China.
Shaohua MaTsinghua Shenzhen International Graduate School (SIGS), Tsinghua University, Shenzhen, China.
Tengfei GuoInstitute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.ORCID 0000-0003-2982-0865
Alzheimer's Disease Neuroimaging Initiative

Funding

National Natural Science Foundation of China 82171197Shenzhen Bay Laboratory 21300061Shenzhen Bay Laboratory S241101004-1the Guangdong Basic and Applied Basic Science Foundation for Distinguished Young Scholars 2023B1515020113the Lingang Laboratory LG-GG-202401-ADA070600the Shenzhen Science and Technology Program RCYX20221008092935096
6 · The paper itself

Abstract

introductionThe spatial and temporal patterns of cortical mean diffusivity (cMD), as well as its association with Alzheimer's disease (AD) and suspected non-Alzheimer's pathophysiology (SNAP), are not yet fully understood.

methodsWe compared baseline (n = 617) and longitudinal changes (n = 421) of cMD, cortical thickness, and gray matter volume and their relations to vascular risk factors, amyloid beta (Aβ), and tau positron emission tomography (PET), and longitudinal cognitive decline in Aβ PET negative and positive older adults.

resultscMD increases were more sensitive to detecting brain structural alterations than cortical thinning and gray matter atrophy. Tau-related cMD increases partially mediated Aβ-related cognitive decline in AD, whereas vascular disease-related increased cMD levels substantially mediated age-related cognitive decline in SNAP. DISCUSSION: These findings revealed the dynamic changes of microstructural and macrostructural indicators and their associations with AD and SNAP, providing novel insights into understanding upstream and downstream events of cMD in neurodegenerative disease. HIGHLIGHTS: Cortical mean diffusivity (cMD) was more sensitive to detecting structural changes than macrostructural factors. Tau-related cMD increases partially mediated amyloid beta-related cognitive decline in Alzheimer's disease (AD). White matter hyperintensity-related higher cMD mainly explained the age-related cognitive decline in suspected non-Alzheimer's pathophysiology (SNAP). cMD may assist in tracking earlier neurodegenerative signs in AD and SNAP.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesPositron-Emission TomographyAgedAged, 80 and overCerebral CortexCognitive DysfunctionFemaleGray MatterHumansLongitudinal StudiesMaletau ProteinsAmyloid beta-Peptidestau ProteinsageAlzheimer's diseasecortical mean diffusivitysuspected non‐Alzheimer's pathophysiologyvascular disease

Identifiers

PMID39132849
PMCPMC11485315

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.