ArticleScientific reports2024
Hebbian plasticity induced by temporally coincident BCI enhances post-stroke motor recovery.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Comparative Effectiveness of Noninvasive Brain-Computer Interface-Based Interventions for Upper Limb Rehabilitation in Poststroke Hemiplegia: Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- The effect of brain-computer interface training on cognitive function in stroke patients: a systematic review and meta-analysis.Journal of neurology · 2026Pooled it
- Brain-computer interface for post-stroke upper-limb recovery: a systematic review integrating clinical efficacy with neuroplasticity evidence.Frontiers in neurology · 2026Pooled it
- Network meta-analysis of different electrical stimulation therapies for lower limb functional rehabilitation in stroke patients.Frontiers in neurology · 2025Pooled it
- The effect of rehabilitation training based on brain-computer interface on limb function in stroke patients: a systematic review and meta-analyses.Frontiers in neurologyPooled it
- Reopening Motor Learning Windows: Targeted Re-Engagement of Latent Pathways via Non-Invasive Neuromodulation.Life (Basel, Switzerland) · 2026Review
- Stroke Rehabilitation, Novel Technology and the Internet of Medical Things.Brain sciences · 2026Review
- Advances in mechanisms of neuroplasticity induced by multimodal closed-loop brain-computer interfaces after stroke.Frontiers in human neuroscience · 2026Review
- Closed-loop brain-computer interfaces for post-stroke sensorimotor loop restoration.Frontiers in neuroscience · 2026Review
- Closed-loop neuromodulation: a paradigm shift in precision neuroscience for clinical and cognitive applications.Frontiers in neuroscience · 2026Review
- Current status and future prospects of brain-computer interfaces in the field of neurological disease rehabilitation.Frontiers in rehabilitation sciences · 2026Review
- Active Rehabilitation Technologies for Post-Stroke Patients.Biosensors · 2025Review
- EMG-guided human-machine interaction training develops new intermuscular coordination patterns in stroke: a pilot study.Journal of neuroengineering and rehabilitation · 2025Article
- Article
- Emerging Therapeutic Strategies in Intracerebral Hemorrhage: Enhancing Neurogenesis and Functional Recovery.MedComm · 2025Review
- Brain-computer interface training for multimodal functional recovery in patients with brain injury: a case series.Quantitative imaging in medicine and surgery · 2025Article
- Brain-Computer Interfaces for Stroke Motor Rehabilitation.Bioengineering (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional electrical stimulation (FES) can support functional restoration of a paretic limb post-stroke. Hebbian plasticity depends on temporally coinciding pre- and post-synaptic activity. A tight temporal relationship between motor cortical (MC) activity associated with attempted movement and FES-generated visuo-proprioceptive feedback is hypothesized to enhance motor recovery. Using a brain-computer interface (BCI) to classify MC spectral power in electroencephalographic (EEG) signals to trigger FES-delivery with detection of movement attempts improved motor outcomes in chronic stroke patients. We hypothesized that heightened neural plasticity earlier post-stroke would further enhance corticomuscular functional connectivity and motor recovery. We compared subcortical non-dominant hemisphere stroke patients in BCI-FES and Random-FES (FES temporally independent of MC movement attempt detection) groups. The primary outcome measure was the Fugl-Meyer Assessment, Upper Extremity (FMA-UE). We recorded high-density EEG and transcranial magnetic stimulation-induced motor evoked potentials before and after treatment. The BCI group showed greater: FMA-UE improvement; motor evoked potential amplitude; beta oscillatory power and long-range temporal correlation reduction over contralateral MC; and corticomuscular coherence with contralateral MC. These changes are consistent with enhanced post-stroke motor improvement when movement is synchronized with MC activity reflecting attempted movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.