Evidence map›Paper›PMID 39134780›Full record

ReviewHeart failure reviews2024

Pharmacological management of heart failure in adults with congenital heart disease.

Barbara Karnkowska, Wissam Harmouch, Peter Newman, Hamza Malik, Bisma Khwaja, Alexandra Lewis, Mohammed Faluk, Khaled Chatila

Abstract readReview
PubMed Publisher
In one paragraph

Review in Heart failure reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Initial care and stabilization of ACHD patients : Teamwork improves outcomes].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Barbara KarnkowskaDepartment of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, 4.174 John Sealy Annex, Galveston, TX, 77555, USA. bekarnko@utmb.edu.ORCID 0009-0007-8001-6414
Wissam HarmouchDepartment of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, 4.174 John Sealy Annex, Galveston, TX, 77555, USA.
Peter NewmanDepartment of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA.
Hamza MalikDepartment of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, 4.174 John Sealy Annex, Galveston, TX, 77555, USA.
Bisma KhwajaDepartment of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, 4.174 John Sealy Annex, Galveston, TX, 77555, USA.
Alexandra LewisUniversity of Texas Medical Branch, John Sealy School of Medicine, Galveston, TX, USA.
Mohammed FalukDivision of Cardiovascular Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Khaled ChatilaDivision of Cardiovascular Medicine, University of Texas Medical Branch, Galveston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital heart disease (CHD) is the most common global congenital defect affecting over 2.4 million individuals in the United States. Ongoing medical and surgical advancements have improved the survival of children with CHD leading to a shift where, as of 2010, adults constitute two-thirds of the CHD patient population. The increasing number and aging of adult congenital heart disease (ACHD) patients present a clinical challenge due to heightened complexity, morbidity, and mortality. Studies indicate that 1 in 13 ACHD patients will develop heart failure (HF) in their lifetime. ACHD-HF patients experience more frequent emergency department visits, higher hospitalization rates, longer hospital stays, and higher mortality compared to non-ACHD patients with heart failure (non-ACHD-HF). Despite HF being the leading cause of death in ACHD patients, there is a notable gap in evidence regarding treatment. While guideline-directed medical therapy (GDMT) has been extensively studied in non-ACHD-HF, research specific to ACHD-HF individuals is limited. This article aims to comprehensively review available literature addressing the pharmacological treatment of ACHD-HF.

Indexed as

Heart Defects, CongenitalHeart FailureAdultHumansACEI/ARBsARNIsBeta blockersCongenital heart diseaseHeart failureMRAsSGLT-2 inhibitors

Identifiers

PMID39134780

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.