Evidence map›Paper›PMID 39135342›Full record

ArticleIUBMB life2024

CD38/cADPR-mediated calcium signaling in a human myometrial smooth muscle cell line, PHM1.

Soner Dogan, Timothy F Walseth, Bilge Guvenc Tuna, Eda Uçar, Mathur S Kannan, Deepak A Deshpande

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IUBMB life, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Soner DoganDepartment of Medical Biology, School of Medicine, Yeditepe University, Istanbul, Turkey.ORCID 0000-0002-7762-8109
Timothy F WalsethDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.
Bilge Guvenc TunaDepartment of Biophysics, School of Medicine, Yeditepe University, Istanbul, Turkey.
Eda UçarDepartment of Medical Biology, School of Medicine, Yeditepe University, Istanbul, Turkey.
Mathur S KannanDepartment of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA.
Deepak A DeshpandeDepartment of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA.ORCID 0000-0002-6187-5332

Funding

Subcellular Targeting/Packaging of Opioids/ReceptorsP50DA011806 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LOH, HORACE · 1998 to 2012
$14.0M
DYNAMIC CALCIUM REGULATION IN AIRWAY SMOOTH MUSCLER01HL057498 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI KANNAN, MATHUR S · 1998 to 2011
$3.0M
NHLBI NIH HHS R01 HL057498NIDA NIH HHS P50 DA011806NIH HHS DA11806NIH HHS HL057498University of Minnesota
6 · The paper itself

Abstract

Cyclic ADP-ribose (cADPR) has emerged as a calcium-regulating second messenger in smooth muscle cells. CD38 protein possesses ADP-ribosyl cyclase and cADPR hydrolase activities and mediates cADPR synthesis and degradation. We have previously shown that CD38 expression is regulated by estrogen and progesterone in the myometrium. Considering hormonal regulation in gestation, the objective of the present study was to determine the role of CD38/cADPR signaling in the regulation of intracellular calcium upon contractile agonist stimulation using immortalized pregnant human myometrial (PHM1) cells. Western blot, immunofluorescence, and biochemical studies confirmed CD38 expression and the presence of ADP-ribosyl cyclase (2.6 ± 0.1 pmol/mg) and cADPR hydrolase (26.8 ± 6.8 nmoles/mg/h) activities on the PHM1 cell membrane. Oxytocin, PGF

Indexed as

ADP-ribosyl Cyclase 1Calcium SignalingCyclic ADP-RiboseMyometriumADP-ribosyl CyclaseCalciumCell LineFemaleHumansMembrane GlycoproteinsMyocytes, Smooth MusclePregnancyUterine ContractionADP-ribosyl CyclaseADP-ribosyl Cyclase 1CalciumCD38 protein, humanCyclic ADP-RiboseMembrane GlycoproteinscADPRCD38endothelin‐1 (ET‐1)hormoneintracellular calciummyometriumoxytocinprostaglandin F2α (PGF2α)smooth muscleuterus

Identifiers

PMID39135342
PMCPMC11580371

What Socratic holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.