ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Educational disparities in brain health and dementia across Latin America and the United States.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Trial
- Reply to "Shifting the emphasis of brain health literacy from individuals to systems to reduce inequalities".Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Social vulnerability shapes deep clinical phenotypes and brain health in aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Urinary copper is linked to regional cortical volume reductions in adolescents with major depressive disorder.Translational psychiatry · 2026Article
- Metabolic, demographic, and behavioral risk factors predict brain structural variability in the general population: an analysis of the human connectome project young adults.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- The exposome of brain aging across 34 countries.Nature medicine · 2026Article
- Mapping the neurovascular landscape in aging and dementia: cerebral small vessel disease markers in a multicenter Latin American cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neural embedding of frailty in cognitively unimpaired aging and dementia across Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cross-sectional and longitudinal cognitive trajectories associated with dementia comorbidity clusters: Results from a 10-year follow-up real-world outpatient memory clinic in Brazil.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Sleep disturbances and Alzheimer's disease: a multiscale approach from exposome to neurobiology and precision medicine.GeroScience · 2026Review
- Impact of cardiometabolic factors and AD plasma biomarkers on white matter hyperintensities volume in individuals with cognitive complaints from the global south.Neuroscience · 2026Article
- Plasma ATN biomarkers across the alzheimer's disease continuum in a Chilean community- and clinic-based cohort.Alzheimer's research & therapy · 2026Article
- Article
- Social disadvantage outweighs knowledge in dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America.Nature aging · 2026Article
- Socio-demographic variables among a group of patients with cognitive decline.Frontiers in psychology · 2026Article
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Prevalence of Neurocognitive Disorders in the Elderly Quechua Population Using the Q-RUDAS.Brain sciences · 2025Article
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Authors and funding
40 authors.
Funding
Abstract
backgroundEducation influences brain health and dementia. However, its impact across regions, specifically Latin America (LA) and the United States (US), is unknown.
methodsA total of 1412 participants comprising controls, patients with Alzheimer's disease (AD), and frontotemporal lobar degeneration (FTLD) from LA and the US were included. We studied the association of education with brain volume and functional connectivity while controlling for imaging quality and variability, age, sex, total intracranial volume (TIV), and recording type.
resultsEducation influenced brain measures, explaining 24%-98% of the geographical differences. The educational disparities between LA and the US were associated with gray matter volume and connectivity variations, especially in LA and AD patients. Education emerged as a critical factor in classifying aging and dementia across regions. DISCUSSION: The results underscore the impact of education on brain structure and function in LA, highlighting the importance of incorporating educational factors into diagnosing, care, and prevention, and emphasizing the need for global diversity in research. HIGHLIGHTS: Lower education was linked to reduced brain volume and connectivity in healthy controls (HCs), Alzheimer's disease (AD), and frontotemporal lobar degeneration (FTLD). Latin American cohorts have lower educational levels compared to the those in the United States. Educational disparities majorly drive brain health differences between regions. Educational differences were significant in both conditions, but more in AD than FTLD. Education stands as a critical factor in classifying aging and dementia across regions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.