Evidence map›Paper›PMID 39136468›Full record

ArticleAntimicrobial agents and chemotherapy2024

Oriana Kreutzfeld, Stephen Orena, Martin Okitwi, Patrick K Tumwebaze, Oswald Byaruhanga, Thomas Katairo, Melissa D Conrad, Jennifer Legac, Shreeya Garg, Rebecca Crudale and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Oriana KreutzfeldUniversity of California, San Francisco, California, USA.ORCID 0000-0003-2026-345X
Stephen OrenaInfectious Diseases Research Collaboration, Kampala, Uganda.
Martin OkitwiInfectious Diseases Research Collaboration, Kampala, Uganda.
Patrick K TumwebazeInfectious Diseases Research Collaboration, Kampala, Uganda.
Oswald ByaruhangaInfectious Diseases Research Collaboration, Kampala, Uganda.
Thomas KatairoInfectious Diseases Research Collaboration, Kampala, Uganda.
Melissa D ConradUniversity of California, San Francisco, California, USA.ORCID 0000-0002-9984-8030
Jennifer LegacUniversity of California, San Francisco, California, USA.
Shreeya GargUniversity of California, San Francisco, California, USA.
Rebecca CrudaleBrown University, Providence, Rhode Island, USA.
Ozkan AydemirProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
David GiesbrechtBrown University, Providence, Rhode Island, USA.
Samuel L NsobyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Benjamin BlascoMedicines for Malaria Venture, Geneva, Switzerland.
Maelle DuffeyMedicines for Malaria Venture, Geneva, Switzerland.
Melanie RouillierMedicines for Malaria Venture, Geneva, Switzerland.
Jeffrey A BaileyBrown University, Providence, Rhode Island, USA.
Roland A CooperDominican University of California, San Rafael, California, USA.ORCID 0000-0002-8437-9382
Philip J RosenthalUniversity of California, San Francisco, California, USA.ORCID 0000-0002-7953-7622

Funding

Resistance of Malaria Parasites to Artemisinin-Based TherapiesR01AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2009 to 2024
$8.4M
Mechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipelineR01AI139179 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Philip Jon Rosenthal · 2018 to 2026
$6.3M
HHS | NIH | OSC | Common Fund (NIH Common Fund) R01AI075045HHS | NIH | OSC | Common Fund (NIH Common Fund) R01AI139179Medicines for Malaria Venture (MMV) RD/15/0001NIAID NIH HHS R01 AI075045NIAID NIH HHS R01 AI139179
6 · The paper itself

Abstract

Novel antimalarials are urgently needed to combat rising resistance to available drugs. The imidazolopiperazine ganaplacide is a promising drug candidate, but decreased susceptibility of laboratory strains has been linked to polymorphisms in the

Indexed as

AntimalarialsDrug ResistancePlasmodium falciparumHumansInhibitory Concentration 50Malaria, FalciparumParasitic Sensitivity TestsPiperazinesProtozoan ProteinsUgandaAntimalarialsPiperazinesProtozoan Proteinsantimalarial drugsdrug susceptibilityganaplacidemalariaPfACTPfCARLPfUGTPlasmodium falciparum

Identifiers

PMID39136468
PMCPMC11373204

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.