Evidence map›Paper›PMID 39137906›Full record

ArticleDatabase : the journal of biological databases and curation2024

ncStem: a comprehensive resource of curated and predicted ncRNAs in cancer stemness.

Hui Liu, Nan Zhang, Yijie Jia, Jun Wang, Aokun Ye, Siru Yang, Honghan Zhou, Yingli Lv, Chaohan Xu, Shuyuan Wang

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In one paragraph

Article in Database : the journal of biological databases and curation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Hui LiuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Nan ZhangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Yijie JiaCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Jun WangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Aokun YeCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Siru YangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Honghan ZhouCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Yingli LvCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.
Chaohan XuCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.ORCID 0000-0001-5145-8757
Shuyuan WangCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China.ORCID 0000-0001-9571-0299

Funding

National Natural Science Foundation of China 61801150 61803130 62272139Natural Science Foundation of Heilongjiang Province LH2022C056 LH2023C102
6 · The paper itself

Abstract

Cancer stemness plays an important role in cancer initiation and progression, and is the major cause of tumor invasion, metastasis, recurrence, and poor prognosis. Non-coding RNAs (ncRNAs) are a class of RNA transcripts that generally cannot encode proteins and have been demonstrated to play a critical role in regulating cancer stemness. Here, we developed the ncStem database to record manually curated and predicted ncRNAs associated with cancer stemness. In total, ncStem contains 645 experimentally verified entries, including 159 long non-coding RNAs (lncRNAs), 254 microRNAs (miRNAs), 39 circular RNAs (circRNAs), and 5 other ncRNAs. The detailed information of each entry includes the ncRNA name, ncRNA identifier, disease, reference, expression direction, tissue, species, and so on. In addition, ncStem also provides computationally predicted cancer stemness-associated ncRNAs for 33 TCGA cancers, which were prioritized using the random walk with restart (RWR) algorithm based on regulatory and co-expression networks. The total predicted cancer stemness-associated ncRNAs included 11 132 lncRNAs and 972 miRNAs. Moreover, ncStem provides tools for functional enrichment analysis, survival analysis, and cell location interrogation for cancer stemness-associated ncRNAs. In summary, ncStem provides a platform to retrieve cancer stemness-associated ncRNAs, which may facilitate research on cancer stemness and offer potential targets for cancer treatment. Database URL: http://www.nidmarker-db.cn/ncStem/index.html.

Indexed as

NeoplasmsNeoplastic Stem CellsRNA, UntranslatedDatabases, GeneticDatabases, Nucleic AcidData CurationHumansMicroRNAsMicroRNAsRNA, Untranslated

Identifiers

PMID39137906
PMCPMC11321241

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.