Evidence mapPaperPMID 39137987Full record

ArticleeNeuro2024

Aperiodic Activity Indexes Neural Hyperexcitability in Generalized Epilepsy.

Markus Kopf, Jan Martini, Christina Stier, Silke Ethofer, Christoph Braun, Yiwen Li Hegner, Niels K Focke, Justus Marquetand, Randolph F Helfrich

Abstract read
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Aperiodic Activity Reflects Pathologic Waveform Shapes in Focal Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Markus KopfHertie Institute for Clinical Brain Research, University Medical Center Tübingen, Tübingen 72076, Germany.
Jan MartiniHertie Institute for Clinical Brain Research, University Medical Center Tübingen, Tübingen 72076, Germany.
Christina StierInstitute for Biomagnetism and Biosignal Analysis, University of Münster, Münster 48149, Germany.ORCID https://orcid.org/0000-0001-5707-4885
Silke EthoferDepartment of Neurosurgery, University Medical Center Tübingen, Tübingen 72076, Germany.
Christoph BraunHertie Institute for Clinical Brain Research, University Medical Center Tübingen, Tübingen 72076, Germany.
Yiwen Li HegnerHertie Institute for Clinical Brain Research, University Medical Center Tübingen, Tübingen 72076, Germany.
Niels K FockeDepartment of Neurology, University Medical Center Göttingen, Göttingen 37075, Germany.
Justus MarquetandHertie Institute for Clinical Brain Research, University Medical Center Tübingen, Tübingen 72076, Germany.
Randolph F HelfrichHertie Institute for Clinical Brain Research, University Medical Center Tübingen, Tübingen 72076, Germany randolph.helfrich@gmail.com.ORCID https://orcid.org/0000-0001-8045-3111

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Generalized epilepsy (GE) encompasses a heterogeneous group of hyperexcitability disorders that clinically manifest as seizures. At the whole-brain level, distinct seizure patterns as well as interictal epileptic discharges (IEDs) reflect key signatures of hyperexcitability in magneto- and electroencephalographic (M/EEG) recordings. Moreover, it had been suggested that aperiodic activity, specifically the slope of the 1/

Indexed as

ElectroencephalographyEpilepsy, GeneralizedMagnetoencephalographyAdolescentAdultBrainBrain WavesFemaleHumansMaleMiddle AgedYoung Adult1/f spectral slopealpha oscillationsaperiodic activityinterictal dischargeslarge-scale hyperexcitabilitynonoscillatory activity

Identifiers

PMID39137987
PMCPMC11376430

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.