Evidence mapPaperPMID 39138299Full record

ReviewCommunications chemistry2024

Cyanine dyes in the mitochondria-targeting photodynamic and photothermal therapy.

Zdeněk Kejík, Jan Hajduch, Nikita Abramenko, Frédéric Vellieux, Kateřina Veselá, Jindřiška Leischner Fialová, Kateřina Petrláková, Kateřina Kučnirová, Robert Kaplánek, Ameneh Tatar and 7 more

Abstract readReview
In one paragraph

Review in Communications chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026
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  7. A CJournal of the American Chemical Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zdeněk KejíkBIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Prague, Czech Republic. Zdenek.Kejik@lf1.cuni.cz.ORCID http://orcid.org/0000-0002-2215-4890
Jan HajduchBIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Prague, Czech Republic.
Nikita AbramenkoBIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Prague, Czech Republic.
Frédéric VellieuxBIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Prague, Czech Republic.ORCID http://orcid.org/0000-0002-1922-5707
Kateřina VeseláBIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Prague, Czech Republic.
Jindřiška Leischner FialováBIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Prague, Czech Republic.
Kateřina PetrlákováDepartment of Pathological Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, CZ-625 00, Brno, Czech Republic.
Kateřina KučnirováBIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Prague, Czech Republic.
Robert KaplánekBIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Prague, Czech Republic.
Ameneh TatarBIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Prague, Czech Republic.ORCID http://orcid.org/0000-0001-8513-2106
Markéta SkaličkováBIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Prague, Czech Republic.
Michal MasaříkBIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Prague, Czech Republic.
Petr BabulaDepartment of Physiology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00, Brno, Czech Republic.
Petr Dytrych1st Department of Surgery-Department of Abdominal, Thoracic Surgery and Traumatology, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 121 08, Prague, Czech Republic.
David Hoskovec1st Department of Surgery-Department of Abdominal, Thoracic Surgery and Traumatology, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 2, 121 08, Prague, Czech Republic.
Pavel MartásekDepartment of Paediatrics and Inherited Metabolic Disorders, First Faculty of Medicine, Charles University and General University Hospital in Prague, Ke Karlovu 455, 120 00, Prague, Czech Republic. Pavel.Martasek@lf1.cuni.cz.ORCID http://orcid.org/0000-0002-0839-8370
Milan JakubekBIOCEV, First Faculty of Medicine, Charles University, 252 50 Vestec, Prague, Czech Republic. Milan.Jakubek@lf1.cuni.cz.ORCID http://orcid.org/0000-0001-7323-3903

Funding

Masarykova Univerzita (Masaryk University) MUNI/A/1587/2023Ministerstvo Školství, Mládeže a Tělovýchovy (Ministry of Education, Youth and Sports) LM2023053Ministerstvo Zdravotnictví Ceské Republiky (Ministry of Health of the Czech Republic) NU21-08-00407Ministerstvo Zdravotnictví Ceské Republiky (Ministry of Health of the Czech Republic) NU22-08-00160Technologická Agentura České Republiky (Technological Agency of the Czech Republic) TN02000109Univerzita Karlova v Praze (Charles University) Cooperatio ONCOUniverzita Karlova v Praze (Charles University) Progres LF1 Q27Univerzita Karlova v Praze (Charles University) Progres LF1 Q38Univerzita Karlova v Praze (Charles University) SVV260521Univerzita Karlova v Praze (Charles University) SVV260637Univerzita Karlova v Praze (Charles University) UNCE 204064
6 · The paper itself

Abstract

Mitochondrial dysregulation plays a significant role in the carcinogenesis. On the other hand, its destabilization strongly represses the viability and metastatic potential of cancer cells. Photodynamic and photothermal therapies (PDT and PTT) target mitochondria effectively, providing innovative and non-invasive anticancer therapeutic modalities. Cyanine dyes, with strong mitochondrial selectivity, show significant potential in enhancing PDT and PTT. The potential and limitations of cyanine dyes for mitochondrial PDT and PTT are discussed, along with their applications in combination therapies, theranostic techniques, and optimal delivery systems. Additionally, novel approaches for sonodynamic therapy using photoactive cyanine dyes are presented, highlighting advances in cancer treatment.

Identifiers

PMID39138299
PMCPMC11322665

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.