Evidence map›Paper›PMID 39138335›Full record

ArticleScientific reports2024

Immunogenicity of a peptide-based vaccine for measles: a pilot evaluation in a mouse model.

Huy Quang Quach, Tamar Ratishvili, Iana H Haralambieva, Inna G Ovsyannikova, Gregory A Poland, Richard B Kennedy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huy Quang QuachMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, 55905, USA.
Tamar RatishviliMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, 55905, USA.
Iana H HaralambievaMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, 55905, USA.
Inna G OvsyannikovaMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, 55905, USA.
Gregory A PolandMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, 55905, USA.
Richard B KennedyMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN, 55905, USA. kennedy.rick@mayo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although neutralizing antibody is an established correlate of protection for measles, T cell-mediated responses play at least two critical roles in immunity to measles: first, through provision of 'help' enabling robust humoral immune responses; and second, through clearance of measles virus-infected cells. Previously, we identified 13 measles-derived peptides that bound to human leukocyte antigen (HLA) molecules in Priess cells infected with measles virus. In this study, we evaluated the immunogenicity of these peptides in a transgenic mouse model. Our results demonstrated that these peptides induced Th1-biased immune responses at varying levels. Of the 13 peptides, the top four immunogenic peptides were further selected for a viral challenge study in mice. A vaccine based on a combination of these four peptides reduced morbidity and weight loss after viral challenge compared to placebo. Our results emphasize the potential of T cell-mediated, peptide-based vaccines against measles.

Indexed as

Disease Models, AnimalMeaslesMeasles VaccineMeasles virusMice, TransgenicVaccines, SubunitAnimalsAntibodies, NeutralizingAntibodies, ViralFemaleHumansImmunogenicity, VaccineMicePeptidesPilot ProjectsTh1 CellsAntibodies, NeutralizingAntibodies, ViralMeasles VaccinePeptidesVaccines, SubunitHLA moleculesInfectious diseasesMeasles vaccineMeasles virusPeptide-based vaccineT cell epitope

Identifiers

PMID39138335
PMCPMC11322560

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.