Evidence map›Paper›PMID 39138796›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2025

Amphiregulin Downregulates E-cadherin Expression by Activating YAP/Egr-1/Slug Signaling in SKOV3 Human Ovarian Cancer Cells.

Qiongqiong Jia, Hailong Wang, Beibei Bi, Xiaoyu Han, Yuanyuan Jia, Lingling Zhang, Lanlan Fang, Avinash Thakur, Jung-Chien Cheng

Abstract read
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qiongqiong Jia *Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Hailong Wang *Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Beibei Bi *Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xiaoyu HanCenter for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yuanyuan JiaCenter for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lingling ZhangCenter for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Lanlan FangCenter for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Avinash ThakurTerry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada.
Jung-Chien ChengCenter for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. jungchien.cheng@gmail.com.ORCID 0000-0002-5399-9327

Funding

Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University QNCXTD2023011National Natural Science Foundation of China 32050410302National Natural Science Foundation of China 32170868
6 · The paper itself

Abstract

Amphiregulin (AREG) stimulates human epithelial ovarian cancer (EOC) cell invasion by downregulating E-cadherin expression. YAP is a transcriptional cofactor that has been shown to regulate tumorigenesis. This study aimed to examine whether AREG activates YAP in EOC cells and explore the roles of YAP in AREG-induced downregulation of E-cadherin and cell invasion. Analysis of the Cancer Genome Atlas (TCGA) showed that upregulation of AREG and EGFR were associated with poor survival in human EOC. Treatment of SKOV3 human EOC cells with AREG induced the activation of YAP. In addition, AREG downregulated E-cadherin, upregulated Egr-1 and Slug, and stimulated cell invasion. Using gain- and loss-of-function approaches, we showed that YAP was required for the AREG-upregulated Egr-1 and Slug expression. Furthermore, YAP was also involved in AREG-induced downregulation of E-cadherin and cell invasion. This study provides evidence that AREG stimulates human EOC cell invasion by downregulating E-cadherin expression through the YAP/Egr-1/Slug signaling.

Indexed as

Adaptor Proteins, Signal TransducingAmphiregulinCadherinsEarly Growth Response Protein 1Ovarian NeoplasmsSnail Family Transcription FactorsTranscription FactorsAntigens, CDCarcinoma, Ovarian EpithelialCell Line, TumorDown-RegulationFemaleGene Expression Regulation, NeoplasticHumansSignal TransductionYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingAmphiregulinAntigens, CDAREG protein, humanCadherinsCDH1 protein, humanEarly Growth Response Protein 1EGR1 protein, humanSNAI1 protein, humanSnail Family Transcription FactorsTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsAmphiregulinE-cadherinEgr-1Ovarian cancerYAP

Identifiers

PMID39138796

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.