Evidence map›Paper›PMID 39139364›Full record

ArticlePain reports2024

Acetaminophen effects upon formalin-evoked flinching, postformalin, and postincisional allodynia and conditioned place preference.

Mijung Yun, Naemi Ditlevsen Regen, Yuvicza Anchondo, Kelly Eddinger, Shelle Malkmus, Steven W Roberts, Elisabetta Donati, Antonio Leonardi, Tony L Yaksh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mijung YunDepartment of Anesthesiology, University of California, San Diego, CA, USA.
Naemi Ditlevsen RegenUniversity of Gothenburg, Gothenburg, Sweden.
Yuvicza AnchondoDepartment of Anesthesiology, University of California, San Diego, CA, USA.
Kelly EddingerDepartment of Anesthesiology, University of California, San Diego, CA, USA.
Shelle MalkmusDepartment of Anesthesiology, University of California, San Diego, CA, USA.
Steven W RobertsMechanical and Aerospace Engineering, University of California San Diego, San Diego, CA, USA.
Elisabetta DonatiSintetica S.A., Via Penate 5, Mendrisio, Switzerland.
Antonio LeonardiSintetica S.A., Via Penate 5, Mendrisio, Switzerland.
Tony L YakshDepartment of Anesthesiology, University of California, San Diego, CA, USA.ORCID https://orcid.org/0000-0003-4297-536X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: We explored in mice, the analgesic, tolerance, dependency, and rewarding effects of systemic acetaminophen (APAP). Methods: Studies employed adult mice (C57Bl6). (1) Results: Formalin in male mice resulted in biphasic flinching and an enduring postformalin tactile allodynia. Acetaminophen dose dependently decreased phase 2 flinching, and reversed allodynia was observed postflinching. At a comparable APAP dose, female mice showed similarly reduced phase 2 flinching. Incision allodynia was transiently reversed by APAP. Repeated APAP delivery showed no loss of effect after sequential injections or signs of withdrawal. Morphine, but not APAP or vehicle, resulted in robust place preference. Conclusions: APAP decreased flinching and allodynia observed following formalin and paw incision and an absence of tolerance, dependence, or rewarding properties.

Indexed as

AcetaminophenConditioned place preferenceDependenceFlinchingFormalinMouseParacetamolRewardTactile allodyniaTolerance

Identifiers

PMID39139364
PMCPMC11321755

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.