Evidence map›Paper›PMID 39139503›Full record

ArticleFree neuropathology2024

Cell-in-cell phenomena of intracellular neutrophils in a recurrent pleomorphic xanthoastrocytoma.

Gianna M Fote, Kamran Urgun, Jordan Davies, Alexander S Himstead, Kevin Gramajo-Aponte, Alexander Lopez, Frank P K Hsu, William H Yong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free neuropathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gianna M FoteUC Irvine School of Medicine, Department of Neurosurgery, University of California, 200 South Manchester Ave, Orange, CA 92868, USA.
Kamran UrgunUC Irvine School of Medicine, Department of Pathology and Laboratory Medicine, University of California, 101 The City Drive South, Orange, CA 92868, USA.
Jordan DaviesUC Irvine School of Medicine, Department of Neurosurgery, University of California, 200 South Manchester Ave, Orange, CA 92868, USA.
Alexander S HimsteadUC Irvine School of Medicine, Department of Neurosurgery, University of California, 200 South Manchester Ave, Orange, CA 92868, USA.
Kevin Gramajo-AponteUC Irvine School of Medicine, University of California, 101 The City Drive South, Orange, CA 92868, USA.
Alexander LopezUC Irvine School of Medicine, Department of Neurosurgery, University of California, 200 South Manchester Ave, Orange, CA 92868, USA.
Frank P K HsuUC Irvine School of Medicine, Department of Neurosurgery, University of California, 200 South Manchester Ave, Orange, CA 92868, USA.
William H YongUC Irvine School of Medicine, Department of Pathology and Laboratory Medicine, University of California, 101 The City Drive South, Orange, CA 92868, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe a case of a young patient with a recurrent pleomorphic xanthoastrocytoma (PXA) showing unusual cell-in-cell (CiC) phenomena. We observed mostly viable but also necrotic neutrophils engulfed within tumor cells. The recurrent tumor was immunopositive for BRAFV600E mutant protein and showed CDKN2 homozygous deletions typical of PXA. Both genetic alterations were also reported in the original primary tumor. Unlike the original tumor that was GFAP and Olig-2 immunopositive, the recurrent neoplasm was largely negative for GFAP and Olig-2 suggesting dedifferentiation. The large malignant cells that contained the neutrophils were negative for histiocytic and lymphohematopoietic markers. Whereas CDKN2 homozygous deletion is common in PXA, its presence is rare in histiocytic neoplasms. Both reactive astrocytes and glial neoplasms very rarely may engulf neutrophils in a process resembling emperipolesis or cellular cannibalism. Future work may clarify which type of CiC pathway is involved.

Indexed as

Brain tumorCase reportCell-in-cellEmperipolesisGliomaPhagocytosisPleomorphic xanthoastrocytoma

Identifiers

PMID39139503
PMCPMC11321259

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.