Evidence map›Paper›PMID 39139558›Full record

ArticleFrontiers in immunology2024

Cereblon deficiency ameliorates carbon tetrachloride-induced acute hepatotoxicity in HepG2 cells by suppressing MAPK-mediated apoptosis.

Seo Young Choi, Parkyong Song, Ji Sun Hwang, You Kyeong Lee, Mi Song Shin, Hong-Joo Son, Yu-Jin Kim, Wanil Kim, Kwang Min Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Seo Young Choi *Department of Life Science and Environmental Biochemistry, Pusan National University, Miryang, Republic of Korea.
Parkyong Song *Department of Convergence Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Ji Sun HwangNew Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea.
You Kyeong LeeDepartment of Life Science and Environmental Biochemistry, Pusan National University, Miryang, Republic of Korea.
Mi Song ShinDepartment of Life Science and Environmental Biochemistry, Pusan National University, Miryang, Republic of Korea.
Hong-Joo SonDepartment of Life Science and Environmental Biochemistry, Pusan National University, Miryang, Republic of Korea.
Yu-Jin KimDepartment of Life Science and Environmental Biochemistry, Pusan National University, Miryang, Republic of Korea.
Wanil KimDepartment of Biochemistry, Department of Convergence Medical Science, and Institute of Medical Science, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Kwang Min LeeDepartment of Life Science and Environmental Biochemistry, Pusan National University, Miryang, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The liver is vulnerable to various hepatotoxins, including carbon tetrachloride (CCl

Indexed as

Adaptor Proteins, Signal TransducingApoptosisCarbon TetrachlorideChemical and Drug Induced Liver InjuryOxidative StressHep G2 CellsHumansMAP Kinase Signaling SystemMitogen-Activated Protein KinasesReactive Oxygen SpeciesUbiquitin-Protein LigasesAdaptor Proteins, Signal TransducingCarbon TetrachlorideCRBN protein, humanMitogen-Activated Protein KinasesReactive Oxygen SpeciesUbiquitin-Protein Ligasescarbon tetrachloridecereblonhepatotoxicityinflammationMAP kinaseoxidative stresspro-inflammatory cytokines

Identifiers

PMID39139558
PMCPMC11319158

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.