Evidence map›Paper›PMID 39140328›Full record

ArticleEuropean heart journal2025

Device-measured physical activity and cardiac structure by magnetic resonance.

Thomas Yates, Cameron Razieh, Joe Henson, Alex V Rowlands, Jonathan Goldney, Gaurav S Gulsin, Melanie J Davies, Kamlesh Khunti, Francesco Zaccardi, Gerry P McCann

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Article in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thomas YatesDiabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK.ORCID 0000-0002-5724-5178
Cameron RaziehDiabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK.ORCID 0000-0003-3597-2945
Joe HensonDiabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK.
Alex V RowlandsDiabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK.
Jonathan GoldneyDiabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK.ORCID 0000-0001-8553-8296
Gaurav S GulsinDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Melanie J DaviesDiabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK.
Kamlesh KhuntiDiabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK.
Francesco ZaccardiDiabetes Research Centre, University of Leicester, Leicester General Hospital, Leicester LE5 4PW, UK.
Gerry P McCannDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.

Funding

Department of Health and Social CareEast MidlandsLeicester Biomedical Research CentreNIHRUK Biobank 33266Wellcome TrustWellcome Trust Leicestershire Healthcare
6 · The paper itself

Abstract

BACKGROUND AND

aimsAlthough extreme cardiac adaptions mirroring phenotypes of cardiomyopathy have been observed in endurance athletes, adaptions to high levels of physical activity within the wider population are under-explored. Therefore, in this study, associations between device-measured physical activity and clinically relevant cardiac magnetic resonance volumetric indices were investigated.

methodsIndividuals without known cardiovascular disease or hypertension were included from the UK Biobank. Cardiac magnetic resonance data were collected between 2015 and 2019, and measures of end-diastolic chamber volume, left ventricular (LV) wall thickness, and LV ejection fraction were extracted. Moderate-to-vigorous-intensity physical activity (MVPA), vigorous-intensity physical activity (VPA), and total physical activity were assessed via wrist-worn accelerometers.

resultsA total of 5977 women (median age and MVPA: 62 years and 46.8 min/day, respectively) and 4134 men (64 years and 49.8 min/day, respectively) were included. Each additional 10 min/day of MVPA was associated with a 0.70 [95% confidence interval (CI): 0.62, 0.79] mL/m2 higher indexed LV end-diastolic volume (LVEDVi) in women and a 1.08 (95% CI: 0.95, 1.20) mL/m2 higher LVEDVi in men. However, even within the top decile of MVPA, LVEDVi values remained within the normal ranges [79.1 (95% CI: 78.3, 80.0) mL/m2 in women and 91.4 (95% CI: 90.1, 92.7) mL/m2 in men]. Associations with MVPA were also observed for the right ventricle and the left/right atria, with an inverse association observed for LV ejection fraction. Associations of MVPA with maximum or average LV wall thickness were not clinically meaningful. Results for total physical activity and VPA mirrored those for MVPA.

conclusionsHigh levels of device-measured physical activity were associated with cardiac remodelling within normal ranges.

Indexed as

ExerciseStroke VolumeAccelerometryAgedFemaleHeart VentriclesHumansMagnetic Resonance ImagingMagnetic Resonance Imaging, CineMaleMiddle AgedVentricular Function, LeftAccelerometerAthletes heartCardiac magnetic resonanceCardiac remodellingLeft ventricular end-diastolic volumeLeft ventricular wall thicknessPhysical activity

Identifiers

PMID39140328
PMCPMC11704417

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.