Evidence map›Paper›PMID 39140361›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Omics-derived biological modules reflect metabolic brain changes in Alzheimer's disease.

Guilherme Povala, Marco Antônio De Bastiani, Bruna Bellaver, Pamela C L Ferreira, João Pedro Ferrari-Souza, Firoza Z Lussier, Diogo O Souza, Pedro Rosa-Neto, Tharick A Pascoal, Bruno Zatt and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Omics-derived biological modules reflect metabolic brain changes in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Guilherme PovalaGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Marco Antônio De BastianiGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Bruna BellaverGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Pamela C L FerreiraDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
João Pedro Ferrari-SouzaGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Firoza Z LussierDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Diogo O SouzaGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, The McGill University Research Centre for Studies in Aging, Montreal, Quebec, Canada.
Tharick A PascoalDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Bruno ZattGraduate Program in Computing, Universidade Federal de Pelotas (UFPEL), Porto Alegre, Brazil.
Eduardo R ZimmerGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Alzheimer's Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Longitudinal multicenter head-to-head harmonization of tau PET tracersR01AG073267 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAKER, SUZANNE L, PASCOAL, THARICK · 2021 to 2025
$41.1M
Head-to-head comparisons of high-performance plasma phospho-tau epitopes for the detection of Alzheimer's diseaseR01AG075336 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tharick Pascoal · 2022 to 2026
$3.7M
Alzheimer's Association #24AARFD-1243899Alzheimer's Association #AARFD-22-974627Alzheimer's Association #AARFD-23-1148735Alzheimer's Association AARGD-21-850670Alzheimer's Association #NIRG-12-92090Alzheimer's Association and Natinal Academy of Neuropsychology ALZ-NAN-22-928381ARD/FAPERGS #21/2551-0000673-0Brain Canada Foundation 33397Brain Canada Foundation 34874Brazilian National Institute of Science and Technology in Excitotoxicity and Neuroprotection #465671/2014-4Canadian Consortium of Neurodegeneration and Aging MOP-11-51-31-team 1CAPES #88887.627297/2021-00CIHR 159815CIHR 162303CIHR #MOP-11-51-31CIHR RFN 152985CNPq #150512/2022-8CNPq 312306/2021-0CNPq 312410/2018-2CNPq 409066/2022-2CNPq 409595/2023-3CNPq 435642/2018-9Fonds de Recherche du Québec - Santé (Chercheur Boursier #2020-VICO-279314Instituto Serrapilheira #Serra-1912-31365NIA NIH HHS R01 AG073267NIA NIH HHS R01AG073267NIA NIH HHS R01 AG075336NIA NIH HHS R01AG075336NIA NIH HHS U01 AG024904Weston Brain Institute
6 · The paper itself

Abstract

introductionBrain glucose hypometabolism, indexed by the fluorodeoxyglucose positron emission tomography ([

methodsHere, we integrated [

resultsOur results showed that multiple transcriptomic modules are associated with brain [ DISCUSSION: By integrating transcriptomics with PET imaging data, we identified that serine/threonine kinase activity-associated genes and zinc-finger-related regulatory units are highly associated with brain metabolic changes in AD. HIGHLIGHTS: We conducted an integrated analysis of system-based transcriptomics and fluorodeoxyglucose positron emission tomography ([

Indexed as

Alzheimer DiseaseBrainFluorodeoxyglucose F18Positron-Emission TomographyAgedAged, 80 and overCognitive DysfunctionFemaleHippocampusHumansMaleTranscriptomeFluorodeoxyglucose F18Alzheimer's diseasefluorodeoxyglucose positron emission tomographysystems biologytranscriptomics

Identifiers

PMID39140361
PMCPMC11485394

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.