Evidence map›Paper›PMID 39141069›Full record

SynthesisEuropean journal of nuclear medicine and molecular imaging2024

Identifying the primary tumour in patients with cancer of unknown primary (CUP) using [

Jeroen R J Willemse, Doenja M J Lambregts, Sara Balduzzi, Winnie Schats, Petur Snaebjornsson, Serena Marchetti, Marieke A Vollebergh, Larissa W van Golen, Zing Cheung, Wouter V Vogel and 6 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. FDG PET Hybrid Imaging.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jeroen R J WillemseDepartment of Radiology, the Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands.
Doenja M J LambregtsDepartment of Radiology, the Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands.
Sara BalduzziDepartment of Biometrics, Netherlands Cancer Institute, Amsterdam, Netherlands.
Winnie SchatsDepartment of Scientific Information Service, Netherlands Cancer Institute, Amsterdam, Netherlands.
Petur SnaebjornssonDepartment of Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Serena MarchettiDepartment of Medical Oncology and Clinical Pharmacology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Marieke A VolleberghDepartment of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Larissa W van GolenDepartment of Nuclear Medicine, Netherlands Cancer Institute, Amsterdam, Netherlands.
Zing CheungDepartment of Nuclear Medicine, Netherlands Cancer Institute, Amsterdam, Netherlands.
Wouter V VogelDepartment of Nuclear Medicine, Netherlands Cancer Institute, Amsterdam, Netherlands.
Zuhir BodalalDepartment of Radiology, the Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands.
Sajjad RostamiDepartment of Radiology, the Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands.
Oke GerkeDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.
Tharani SivakumaranDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Regina G H Beets-TanDepartment of Radiology, the Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands.
Max J LahayeDepartment of Radiology, the Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands. mj.lahaye@gmail.com.ORCID 0000-0002-8444-202X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn this systematic review and individual patient data (IPD) meta-analysis, we analysed the diagnostic performance of [

methodsA systematic literature search from January 2005 to February 2024 was performed to identify articles describing the diagnostic performance of [

resultsA total of 1865 patients from 32 studies were included. The largest subgroup included patients with predominant bone metastases (n = 622), followed by liver (n = 369), lymph node (n = 358), brain (n = 316), peritoneal (n = 70), lung (n = 67), and soft tissue (n = 23) metastases, leaving a small group of other/undefined metastases (n = 40). [

conclusionThis individual patient data meta-analysis suggests that the ability of [

Indexed as

Fluorodeoxyglucose F18Neoplasms, Unknown PrimaryPositron Emission Tomography Computed TomographyHumansRadiopharmaceuticalsFluorodeoxyglucose F18Radiopharmaceuticals[18F]FDG PET/CTCancer of unknown primaryMeta-analysisMolecular imagingOncology

Identifiers

PMID39141069
PMCPMC11599304

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.