Evidence map›Paper›PMID 39141573›Full record

ArticleAmerican journal of respiratory cell and molecular biology2025

A-Kinase-Anchoring Protein Subtypes Differentially Regulate GPCR Signaling and Function in Human Airway Smooth Muscle.

Elham Javed, Ajay P Nayak, Arun K Jannu, Aaron H Cohen, Isabella Dewes, Ruping Wang, Dale D Tang, Deepak A Deshpande, Raymond B Penn

Abstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Airway Smooth Muscle Dysfunction in Asthma: Releasing the Anchor.American journal of respiratory cell and molecular biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Elham JavedDepartment of Medicine Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania; and.ORCID 0000-0002-8867-0724
Ajay P NayakDepartment of Medicine Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania; and.ORCID 0000-0003-3437-0096
Arun K JannuDepartment of Medicine Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania; and.
Aaron H CohenDepartment of Medicine Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania; and.
Isabella DewesDepartment of Medicine Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania; and.
Ruping WangDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York.
Dale D TangDepartment of Molecular and Cellular Physiology, Albany Medical College, Albany, New York.ORCID 0000-0002-7339-9249
Deepak A DeshpandeDepartment of Medicine Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania; and.ORCID 0000-0002-6187-5332
Raymond B PennDepartment of Medicine Pulmonary and Critical Care Medicine, Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, Pennsylvania; and.ORCID 0000-0001-8452-5880

Funding

G Protein-Coupled Receptor Signaling in Airway Smooth MuR01HL058506 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RAYMOND B. PENN · 2001 to 2026
$9.3M
Reorganization of the Actin Cytoskeleton in Airway Smooth MuscleR01HL110951 · NHLBI · ALBANY MEDICAL COLLEGE · PI TANG, DALE D. · 2012 to 2022
$3.6M
PLK1 Regulation of Airway Smooth MuscleR01HL130304 · NHLBI · ALBANY MEDICAL COLLEGE · PI TANG, DALE D. · 2016 to 2024
$3.5M
tRNA-derived non-coding RNAs in ASM function and in asthmaR01HL150560 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI DESHPANDE, DEEPAK A, KIRINO, YOHEI · 2020 to 2023
$2.4M
Compartmentalized signaling and crosstalk in airway myocytesR01HL169522 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI RENNOLDS S OSTROM, RAYMOND B. PENN · 2023 to 2026
$2.2M
Functional Diversity of Compartmentalized Calcium Signaling in Airway Smooth MuscleR01HL137030 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI DESHPANDE, DEEPAK A · 2018 to 2021
$2.2M
Mitochondrial translocator protein: a target for bronchodilationR01HL153602 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI NAYAK, AJAY · 2021 to 2025
$2.0M
Cooperative targeting of pharmacomechanical coupling and the actin cytoskeleton to regulate ASM contractionR01HL145392 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI KRISHNAN, RAMASWAMY, PENN, RAYMOND B. · 2019 to 2022
$1.9M
BETA ADRENERGIC RECEPTOR REGULATION IN HUMAN AIRWAY MUSCR29HL058506 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI PENN, RAYMOND B. · 1997 to 2000
$113k
NHLBI NIH HHS HL058506NHLBI NIH HHS HL137030NHLBI NIH HHS HL145392NHLBI NIH HHS HL150560NHLBI NIH HHS HL153602NHLBI NIH HHS HL169522NHLBI NIH HHS R01 HL058506NHLBI NIH HHS R01 HL130304NHLBI NIH HHS R01 HL137030NHLBI NIH HHS R01 HL145392NHLBI NIH HHS R01 HL150560NHLBI NIH HHS R01 HL153602NHLBI NIH HHS R01 HL169522NHLBI NIH HHS R29 HL058506
6 · The paper itself

Abstract

AKAPs (A-kinase-anchoring proteins) act as scaffold proteins that anchor the regulatory subunits of the cAMP-dependent PKA (protein kinase A) to coordinate and compartmentalize signaling elements and signals downstream of Gs-coupled GPCRs (G protein-coupled receptors). The β

Indexed as

A Kinase Anchor ProteinsMuscle, SmoothMyocytes, Smooth MuscleReceptors, G-Protein-CoupledSignal TransductionCell Adhesion MoleculesCell MovementCells, CulturedCyclic AMP-Dependent Protein KinasesCytoskeletal ProteinsEzrinHSP20 Heat-Shock ProteinsHumansMicrofilament ProteinsPhosphoproteinsPhosphorylationA Kinase Anchor ProteinsCell Adhesion MoleculesCyclic AMP-Dependent Protein KinasesCytoskeletal ProteinsEzrinHSP20 Heat-Shock ProteinsMicrofilament ProteinsPhosphoproteinsReceptors, Adrenergic, beta-2Receptors, G-Protein-CoupledReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 SubtypeVasodilator-Stimulated PhosphoproteinAKAPsASMcell migrationG protein–coupled receptorprostaglandin

Identifiers

PMID39141573
PMCPMC11976650

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.