ArticleThe New England journal of medicine2024
An Accurate and Rapidly Calibrating Speech Neuroprosthesis.
Registry-linked trialAbstract readCase Reports
In one paragraph
Article in The New England journal of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00912041 (BrainGate2), which is not on this map. Cited by 91 papers.
0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Who cites it
91 citing papers in PubMed.
- Speech motor cortex enables BCI cursor control and click.Journal of neural engineering · 2025Trial
- How different immersive environments affect intracortical brain computer interfaces.Journal of neural engineering · 2025Trial
- Restoring rapid natural bimanual typing with a neuroprosthesis after paralysis.Nature neuroscience · 2026Article
- Functional near-infrared spectroscopy: Systematic mapping of abnormal brain function features in neurological disorders.Neural regeneration research · 2026Article
- In conversation with Sergey Stavisky.Nature neuroscience · 2026Article
- Simultaneous speech and gesture decoding for multimodal communication in paralysis.Nature neuroscience · 2026Article
- Noninvasive decoding of typed sentences from human brain activity.Nature neuroscience · 2026Article
- Assistive algorithms influence neural representations in motor brain-computer interfaces.Nature communications · 2026Article
- Speech Brain-Computer Interfaces: A New Pathway for Restoring Communication in Anarthria.Neuroscience bulletin · 2026Article
- [Analysis of the constraints of inherent limitations on the capability boundaries of brain-computer interfaces and corresponding strategies].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Review
- A language network in the individualized functional connectomes of 1199 human brains doing arbitrary tasks.Nature communications · 2026Article
- Optimal Size of Electrocorticography Grids for Classification of Hand Movements.Neuroinformatics · 2026Article
- Article
- Article
- Advancing data protections for implantable brain-computer interfaces.Communications medicine · 2026Review
- Frequency-dependent effects of motor thalamus deep brain stimulation on speech and swallowing.Nature communications · 2026Article
- Shared latent representations of speech production for cross-patient speech decoding.Nature communications · 2026Article
- Learning-related population dynamics in right and left dorsal premotor cortex during typing skill acquisition.bioRxiv : the preprint server for biology · 2026Article
- Long-term independent use of an intracortical brain-computer interface for speech and cursor control.Nature medicine · 2026Article
- Intracortical BCI Performance is Robust to Changes in Attentional Load During Dual-Tasking.bioRxiv : the preprint server for biology · 2026Article
31 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
18 authors.
Nicholas S CardFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).ORCID 0000-0002-6858-268X
Maitreyee WairagkarFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Carrina IacobacciFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Xianda HouFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Tyler Singer-ClarkFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Francis R WillettFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Erin M KunzFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Chaofei FanFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Maryam Vahdati NiaFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Darrel R DeoFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Aparna SrinivasanFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Eun Young ChoiFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Matthew F GlasserFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Leigh R HochbergFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).ORCID 0000-0003-0261-2273
Jaimie M HendersonFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Kiarash ShahlaieFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
Sergey D StaviskyFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).
David M BrandmanFrom the Departments of Neurological Surgery (N.S.C., M.W., C.I., X.H., T.S.-C., M.V.N., A.S., K.S., S.D.S., D.M.B.), Computer Science (X.H., M.V.N.), and Biomedical Engineering (T.S.-C., A.S.), University of California, Davis, Davis, and the Departments of Neurosurgery (D.R.D., E.Y.C., J.M.H.), Electrical Engineering (E.M.K.), and Computer Science (C.F.), the Wu Tsai Neurosciences Institute (E.M.K., J.M.H.), the Howard Hughes Medical Institute (F.R.W.), and Bio-X (J.M.H.), Stanford University, Stanford - both in California; the Departments of Radiology and Neuroscience, Washington University School of Medicine, Saint Louis (M.F.G.); the School of Engineering and Carney Institute for Brain Sciences, Brown University (L.R.H.), and the Center for Neurorestoration and Neurotechnology, Department of Veterans Affairs Office of Rehabilitation Research and Development, VA Providence Healthcare (L.R.H.) - both in Providence, RI; and the Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (L.R.H.).ORCID 0000-0003-3224-7019
Funding
RECONSTRUCTIONS AND REPRESENTATIONS OF CEREBRAL CORTEXR01MH060974 · NIMH · WASHINGTON UNIVERSITY · PI VAN ESSEN, DAVID C · 1999 to 2024
$12.7MSingle-neuron population dynamics in human speech motor cortex for a speech prosthesisU01DC019430 · NIDCD · STANFORD UNIVERSITY · PI Shaul Druckmann, JAIMIE M HENDERSON · 2021 to 2026
$4.5MIntuitive, complete neural control of tablet computers for communicationU01DC017844 · NIDCD · BROWN UNIVERSITY · PI HOCHBERG, LEIGH R · 2019 to 2025
$4.3MUnderstanding and restoring speech production using an intracortical brain-computer interfaceDP2DC021055 · NIDCD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI STAVISKY, SERGEY · 2022 to 2025
$2.3MBrainGate: Robust Neural Decoding for Veterans with ALSI01RX002295 · VA · PROVIDENCE VA MEDICAL CENTER · PI HOCHBERG, LEIGH R · 2017 to 2025
–Congressionally Directed Medical Research Programs AL220043NIDCD NIH HHS DP2 DC021055NIDCD NIH HHS DP2DC021055NIDCD NIH HHS U01 DC017844NIDCD NIH HHS U01 DC019430NIDCD NIH HHS U01DC019430NIDCD NIH HHS U01DC17844NIMH NIH HHS R01 MH060974RRD VA I01 RX002295Simons Foundation 872146SPIU.S. Department of Veterans Affairs A2295-R
Abstract
backgroundBrain-computer interfaces can enable communication for people with paralysis by transforming cortical activity associated with attempted speech into text on a computer screen. Communication with brain-computer interfaces has been restricted by extensive training requirements and limited accuracy.
methodsA 45-year-old man with amyotrophic lateral sclerosis (ALS) with tetraparesis and severe dysarthria underwent surgical implantation of four microelectrode arrays into his left ventral precentral gyrus 5 years after the onset of the illness; these arrays recorded neural activity from 256 intracortical electrodes. We report the results of decoding his cortical neural activity as he attempted to speak in both prompted and unstructured conversational contexts. Decoded words were displayed on a screen and then vocalized with the use of text-to-speech software designed to sound like his pre-ALS voice.
resultsOn the first day of use (25 days after surgery), the neuroprosthesis achieved 99.6% accuracy with a 50-word vocabulary. Calibration of the neuroprosthesis required 30 minutes of cortical recordings while the participant attempted to speak, followed by subsequent processing. On the second day, after 1.4 additional hours of system training, the neuroprosthesis achieved 90.2% accuracy using a 125,000-word vocabulary. With further training data, the neuroprosthesis sustained 97.5% accuracy over a period of 8.4 months after surgical implantation, and the participant used it to communicate in self-paced conversations at a rate of approximately 32 words per minute for more than 248 cumulative hours.
conclusionsIn a person with ALS and severe dysarthria, an intracortical speech neuroprosthesis reached a level of performance suitable to restore conversational communication after brief training. (Funded by the Office of the Assistant Secretary of Defense for Health Affairs and others; BrainGate2 ClinicalTrials.gov number, NCT00912041.).
Indexed as
Amyotrophic Lateral SclerosisBrain-Computer InterfacesDysarthriaSpeechCalibrationCommunication Devices for People with DisabilitiesElectrodes, ImplantedHumansMaleMicroelectrodesMiddle AgedQuadriplegia
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT00912041ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.